China Stroke Primary Prevention Trial: Visit-to-Visit Systolic Blood Pressure Variability Is an Independent Predictor of Primary Stroke in Hypertensive Patients Stroke

ConclusionsVisit‐to‐visit SBP variability is an independent predictor of primary stroke in Chinese hypertensive patients. This predictive value depends on the number of blood pressure measurements used to calculate variability but is independent of mean SBP.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00794885.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Epidemiology, Hypertension, Cerebrovascular Disease/Stroke Original Research Source Type: research

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In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Blood pressure details the force of your blood against your arteries. If this force becomes high enough, it can lead to health problems, such as heart attacks and strokes. The good news is that simple lifestyle interventions can lower this force. This includes a popular breakfast drink that could lower high blood pressure by as much as cutting down on salt.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: These data are in accordance with current evidence and should be thoroughly assessed in order to ensure optimal therapeutic management of stroke patients.PMID:35062158 | DOI:10.3233/SHTI210925
Source: Studies in Health Technology and Informatics - Category: Information Technology Authors: Source Type: research
Int J Mol Sci. 2022 Jan 16;23(2):952. doi: 10.3390/ijms23020952.ABSTRACTCardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In thi...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Neurol Neurochir Pol. 2022 Jan 21. doi: 10.5603/PJNNS.a2022.0010. Online ahead of print.ABSTRACTAIM OF THE STUDY: To assess the influence of age on long-term functional outcome in patients with acute ischaemic stroke (AIS) treated with intravenous thrombolysis (IVT).MATERIAL AND METHODS: We performed retrospective analysis of 362 AIS patients treated with IVT or IVT and subsequent mechanical thrombectomy in the University Hospital in Krakow, Poland. Patients were categorised into four subgroups by age: (I) below the age of 60, (II) 60 to 69, (III) 70 to 79, and (IV) 80 or more. The outcomes were assessed with modified Rank...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Source Type: research
Int J Mol Sci. 2022 Jan 16;23(2):952. doi: 10.3390/ijms23020952.ABSTRACTCardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In thi...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Neurol Neurochir Pol. 2022 Jan 21. doi: 10.5603/PJNNS.a2022.0010. Online ahead of print.ABSTRACTAIM OF THE STUDY: To assess the influence of age on long-term functional outcome in patients with acute ischaemic stroke (AIS) treated with intravenous thrombolysis (IVT).MATERIAL AND METHODS: We performed retrospective analysis of 362 AIS patients treated with IVT or IVT and subsequent mechanical thrombectomy in the University Hospital in Krakow, Poland. Patients were categorised into four subgroups by age: (I) below the age of 60, (II) 60 to 69, (III) 70 to 79, and (IV) 80 or more. The outcomes were assessed with modified Rank...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Source Type: research
SARS-Cov-2 infection may be complicated by atrial flutter, hypercoagulability, TIA, superinfection, and sepsis. AbstractSARS-CoV-2  may not only manifest as pneumonia (COVID-19) but also in other organs, including the brain (neuro-COVID). One of the cerebral complications of SARS-CoV-2 is ischemic stroke. Transitory ischemic attack (TIA) in a SARS-CoV-2 positive has not been reported. A 78-year-old poly-morbid male (diabetes, hypertension, and coronary heart disease), admitted for COVID-19, developed atrial flutter on hospital day (hd) 2. Anticoagulation with enoxaparin was started. On hd5, he experienced a TIA despit...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
This study was designed to explore possible differentially expressed genes (DEGs) that contribute to the pathophysiology of hypertension. To identify the DEGs of HTN, we investigated 22 publicly available cDNA Affymetrix datasets using an integrated system-level framework. Gene Ontology (GO), pathway enrichment, and transcriptional factors were analyzed to reveal biological information. From 50 DEGs, we ranked 7 hypertension-related genes (p-value < 0.05): ADM, ANGPTL4, USP8, EDN, NFIL3, MSR1, and CEBPD. The enriched terms revealed significant functional roles of HIF-1-α transcription; endothelin; GPCR-bin...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Medicine (Baltimore). 2021 Dec 3;100(48):e28155. doi: 10.1097/MD.0000000000028155.ABSTRACTAtraumatic convexity subarachnoid hemorrhage (c-SAH) concomitant with large artery atherosclerosis (LAA) stroke has been rarely discussed in the literature. Our aim in this study is to characterize the clinical and neuroradiological features of patients with LAA stroke and c-SAH.A retrospective study from a single institution was performed between January 2016 and June 2020. Only patients diagnosed with c-SAH and LAA stoke were included in this study. The clinical presentation and neuroimaging finding were summarized by our experience...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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