Circulating microRNAs: Potential Markers of Cardiotoxicity in Children and Young Adults Treated With Anthracycline Chemotherapy [Heart Failure]

ConclusionsIn this pilot study, cardiac‐related plasma miRNAs are dysregulated following ACs. Plasma miR‐29b and ‐499 are acutely elevated post‐AC, with dose response relationships observed with anthracycline dose and markers of cardiac injury. Further evaluation of miRNAs may provide mechanistic insight into AC‐induced cardiotoxicity and yield biomarkers to facilitate earlier intervention to mitigate cardiotoxicity.

Source: JAHA:Journal of the American Heart Association - April 4, 2017 Category: Cardiology Authors: Leger, K. J., Leonard, D., Nielson, D., de Lemos, J. A., Mammen, P. P. A., Winick, N. J. Tags: Biomarkers, Pediatrics, Cardiomyopathy, Complications Original Research Source Type: research