Postmenopausal hormone therapy associated with higher risk of hearing loss

(Brigham and Women's Hospital) Use of postmenopausal hormone therapy was associated with higher risk of hearing loss, and the risk tended to increase with longer duration of use.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Grandi G, Caroli M, Cortesi L, Toss A, Tazzioli G, Facchinetti F Abstract INTRODUCTION: Risk-reducing-salpingo-oophorectomy (RRSO) inevitably leads BRCA mutation carriers to premature menopause. AREAS COVERED: To evaluate the existing evidence for use of postmenopausal hormone therapy (HT) in BRCAmc, after RRSO or menopause occurring naturally, for both breast cancer (BC) survivors and those without BC. EXPERT OPINION: All BC survivors are excluded from any HT treatment: in other BRCAmc, before 51 years of age the benefits of HT overcome the risks after RRSO and/or premature ovarian insufficie...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. Int J Mol Med. 2020 Aug;46(2):817-827 Authors: Chen X, Yin T, Zhang B, Sun B, Chen J, Xiao T, Wang B, Li M, Yang J, Fan X Abstract Breakthroughs in cancer management result from the development of drugs that can be used for early diagnosis and effective treatment. Surgery, chemotherapy, radiotherapy and hormone therapy are the main anticancer therapies. However, traditional cancer chemotherapy is associated w...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
CONCLUSIONS: Based on the results of this research, TS is increasingly diagnosed at a later age. The effect of rhGH therapy was favorable and resulted in a greater height gain in the treated patients. PMID: 32623843 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
We present a narrative review of the benefits versus risks of using MHT in the management of postmenopausal osteoporosis. Current literature suggests robust anti-fracture efficacy of MHT in patients unselected for low BMD, regardless of concomitant use with progestogens, but with limited evidence of persisting skeletal benefits following cessation of therapy. Side effects include cardiovascular events, thromboembolic disease, stroke and breast cancer, but the benefit-risk profile differs according to the use of opposed versus unopposed oestrogens, type of oestrogen/progestogen, dose and route of delivery and, for cardiovas...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Condition:   Breast Cancer Interventions:   Behavioral: educational yoga program;   Other: no intervention Sponsor:   Institut du Cancer de Montpellier - Val d'Aurelle Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report a case of a patient treated with tamoxifen 20mg daily as hormone therapy for breast cancer. On regular ophthalmological follow-up, tamoxifen maculopathy was detected on SD-OCT (Spectral Domain Optic Coherence Tomography, Carl Zeiss Meditec®), so the medication was discontinued. Despite discontinuation of the medication, the maculopathy progressed over time. We have been following our patient for seven years. Tamoxifen may produce a toxic maculopathy which may progress despite discontinuation of the medication. We consider our case interesting, given the lengthy follow-up of the patient with sequential SD-OCT ...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
IJERPH, Vol. 17, Pages 4875: Emirati Women’s Knowledge about the Menopause and Menopausal Hormone Therapy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17134875 Authors: Linda Smail Ghufran A. Jassim Khawla I. Sharaf The aim of this study was to investigate the knowledge of Emirati women aged 30–64 about menopause, menopausal hormone therapy (MHT), and their associated health risks, and additionally, to determine the relationships between Emirati women’s knowledge about menopause and their sociodemographic and reproductive characteristics. A commu...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractPurpose of ReviewThis review will clarify the complex relationship of hormonal contraception and mood in women both with and without mood disorders, in adolescents, and in postpartum women.Recent FindingsThough the overall effect of hormonal contraception on mood does not appear to have a significant clinical impact, several recent population-based studies suggest adolescents are potentially more vulnerable than adults.SummaryStrategic initiation of hormonal contraception may mitigate mood symptoms, with continuous regimens of hormonal therapy demonstrating some benefit over cyclic regimens. Additional rigorous stu...
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research
e EL, Goodman MT, Harris HR, Høgdall E, Huntsman DG, Shen H, Jensen A, Johnatty SE, Jordan SJ, Kjaer SK, Kupryjanczyk J, Lambrechts D, McLean K, Menon U, Modugno F, Moysich K, Ness R, Ramus SJ, Richardson J, Risch H, Rossing MA, Trabert B, Wentzensen N, Ziogas A, Terry KL, Wu AH, Hanley GE, Pharoah P, Webb PM, Pike MC, Pearce CL, Ovarian Cancer Association Consortium Abstract PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 po...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Publication date: Available online 3 July 2020Source: Journal of Clinical &Translational EndocrinologyAuthor(s): Pichatorn Suppakitjanusant, Yuhan Ji, Mary Stevenson, Panicha Chantrapanichkul, R. Craig Sineath, Michael Goodman, Jessica A. Alvarez, Vin Tangpricha
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
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