Clinical characteristics and PRRT2 gene mutation analysis of sporadic patients with paroxysmal kinesigenic dyskinesia in China

Paroxysmal kinesigenic dyskinesia (PKD) is a rare kind of paroxysmal movement disorders, which is characterized by recurrent brief episodes of dystonia,athetosis,chorea or a combination. And PKD is triggered by initiation of voluntary movements. It mainly affects children. Each occurrence last a few seconds, with recurring at variable frequency, and without any disturbance of consciousness. Severity of attacks diminished with age. PKD response well to anti-epileptic drugs (AEDs) [1,2]. Most of the reported cases of PKD are familial and inherited in an autosomal dominant trait.
Source: Clinical Neurology and Neurosurgery - Category: Neurosurgery Authors: Source Type: research