Imbalance in cortical inhibition-excitation networks underlies als

Conclusions The present study has established that cortical hyperexcitabilty in ALS is mediated through a combination of reduced inhibition (implying dysfunction of inhibitory circuits) combined with increased activity of the excitatory cortical networks. Strategies aimed at modulating the imbalance in cortical inhibition-excitation axis may prove therapeutically useful.

http://jnnp.bmj.com/cgi/content/short/88/5/e1-l?rss=1

Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Bos, M. A. V. d., Geevasinga, N., Menon, P., Kiernan, M. C., Vucic, S. Tags: Abstracts Source Type: research