Idiosyncratic drug-induced neutropenia and agranulocytosis

Conclusion:</strong> The present study demonstrated that idiosyncratic drug-induced agranulocytosis is a relative rare events; that antibiotics, antithyroid, neuroleptic and anti-epileptic agents, and platelet aggregation inhibitors are the main incriminated drug classes; that agranulocytosis typically serious, with at least 50% exhibiting severe sepsis and a mortality rate<10%; and that modern management of such disorder may reduce the infection-related mortality.</span>
Source: QJM - Category: Internal Medicine Source Type: research