Log in to search using one of your social media accounts:

 

The spectrum of REM sleep-related episodes in children with type 1 narcolepsy - Antelmi E, Pizza F, Vandi S, Neccia G, Ferri R, Bruni O, Filardi M, Cantalupo G, Liguori R, Plazzi G.

Type 1 narcolepsy is a central hypersomnia due to the loss of hypocretin-producing neurons and characterized by cataplexy, excessive daytime sleepiness, sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep. In children, close to the dis...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Related Links:

Conclusion: Almost 60% SDB patients had severe OSA and almost 35% of all SDB patients had an AHI>60/hr. AF in our series is very uncommon present in only 0.5 % patients of SDB. Indians had relatively higher OSA severity than African patients. Also MPT and ESS were significantly higher among Indians
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Abstract Effectiveness and side-effect profile data on pharmacotherapy for daytime sleepiness in central hypersomnias are based largely upon randomized controlled trials. Evidence regarding the use of combination therapy is scant. The aim of this study was to examine the effectiveness and occurrence of drug-related side effects of these drugs in routine clinical practice. Adult patients diagnosed with a central hypersomnia during a 54-month period at a tertiary sleep disorders centre were identified retrospectively. Side effects were recorded at every follow-up visit. A total of 126 patients, with 3275 patient-mon...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
/Background: Cataplexy is the pathognomonic symptom of narcolepsy type 1 (NT1). Since it is considered difficult to be directly observed or documented by clinicians, its diagnosis relies mainly on history taking. Our study aimed at testing the feasibility of a standardized video recording procedure under emotional stimulation to document cataplexy in the diagnostic work-up of suspected hypersomnia of central origin.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Source Type: research
Summary Effectiveness and side‐effect profile data on pharmacotherapy for daytime sleepiness in central hypersomnias are based largely upon randomized controlled trials. Evidence regarding the use of combination therapy is scant. The aim of this study was to examine the effectiveness and occurrence of drug‐related side effects of these drugs in routine clinical practice. Adult patients diagnosed with a central hypersomnia during a 54‐month period at a tertiary sleep disorders centre were identified retrospectively. Side effects were recorded at every follow‐up visit. A total of 126 patients, with 3275 patient‐mon...
Source: Journal of Sleep Research - Category: Neurology Authors: Tags: Regular Research Paper Source Type: research
Abstract PURPOSE: The purpose of this study is to evaluate whether damage to the hypothalamus due to craniopharyngioma or consequent surgery may involve the sleep-wake regulatory system, resulting in sleep disturbances and sleepiness. METHODS: Seven craniopharyngioma patients and 10 healthy controls were evaluated with sleep questionnaires including the Epworth Sleepiness Scale, polysomnography, and a multiple sleep latency test (MSLT). Five patients and eight controls had lumbar puncture performed to determine hypocretin-1 levels. RESULTS: Patients tended to feel sleepier than control individuals of the...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
The major diagnostic sleep laboratory tool for assessing excessive daytime sleepiness (EDS), the multiple sleep latency test (MSLT), is increasingly criticized for poor precision in the differentiation of idiopathic hypersomnia (IH) and narcolepsy (Trotti et al., 2013; Johns, 2000). Recent evidence suggests that actigraphy can supplement the diagnostic process by providing information about the sleep-wake rhythm (Kretzschmar et al., 2016; Filardi et al., 2015; Bruck et al., 2005). An actigraphy analysis tool is introduced that processes actigraphy recordings with machine learning methods.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Poster Source Type: research
Authors: Ferini-Strambi L, Sforza M, Poletti M, Giarrusso F, Galbiati A Abstract Excessive Daytime Sleepiness (EDS) is a common condition with a significant impact on quality of life and general health. A mild form of sleepiness can be associated with reduced reactivity and modest distractibility symptoms, but more severe symptomatic forms are characterized by an overwhelming and uncontrollable need to sleep, causing sudden sleep attacks, amnesia and automatic behaviors. The prevalence in the general population is between 10 and 25%. Furthermore, EDS has been considered a core symptom of obstructive sleep apnea (OS...
Source: Medicina del Lavoro - Category: Occupational Health Tags: Med Lav Source Type: research
ConclusionsPediatric patients with EDS had various sleep disorders and some did not have any sleep disorder despite EDS. More than half the patients with EDS showed depressive feelings affecting their daily lives. For pediatric patients with EDS, a systematic diagnostic approach including questionnaires for sleep habits and emotion and PSG is essential for accurate diagnosis and treatment.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: Pediatric patients with EDS had various sleep disorders and some did not have any sleep disorder despite EDS. More than half the patients with EDS showed depressive feelings affecting their daily lives. For pediatric patients with EDS, a systematic diagnostic approach including questionnaires for sleep habits and emotion and PSG is essential for accurate diagnosis and treatment. PMID: 28822033 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
Current diagnostic criteria of narcolepsy types 1 (NT1), type 2 (NT2) and idiopathic hypersomnia (IH), including clinical, electrophysiological and biologic criteria are listed in the International classification of sleep disorders, 3rd edition (ICSD-3). Electrophysiological criteria have been recently weakened with the demonstration that the multiple sleep latency test (MSLT) has poor test/retest reliability. Thus the search for additional electrophysiological criteria for these central disorders of hypersomnolence.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Symposium XV. – Registering sleep objectively Source Type: research
More News: Brain | Children | Hypersomnia | Narcolepsy | Neurology | Sleep Disorders | Sleep Medicine