Transmission of Donor-Derived Breast Carcinoma as a Recurrent Mass in a Keratolimbal Allograft

Conclusions: We report a case of donor-derived breast carcinoma in a keratolimbal allograft recipient. The grafted tissue harbored donor-derived tumor cells for more than 4 years after surgery even after systemic immunosuppression was discontinued. Although no similar reports of tumor transfer could be found in the literature, this case suggests the need for increased stringency in donor selection and heightened surveillance for such tumor transmission.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research

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ConclusionsThis study contains the largest population dataset of ILC evaluated to date. While total breast cancer incidence rates in Ontario are largely unchanged, ILC incidence rates are steadily increasing and there is a trend towards diagnosis of ILC at a later stage. These trends highlight the ongoing diagnostic and treatment challenge ILC presents for patients and clinicians.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
AbstractBackgroundAlthough rates of total skin-sparing (nipple-sparing) mastectomies are increasing, the oncologic safety of this procedure has not been evaluated in invasive lobular carcinoma (ILC). ILC is the second most common type of breast cancer, and its diffuse growth pattern and high positive margin rates potentially increase the risk of poor outcomes from less extensive surgical resection.MethodsWe compared time to local recurrence and positive margin rates in a cohort of 300 patients with ILC undergoing either total skin-sparing mastectomy (TSSM), skin-sparing mastectomy, or simple mastectomy between the years 20...
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo investigate the performance of an imaging and biopsy parameters-based multivariate model in decreasing unnecessary surgeries for high-risk breast lesions.MethodsIn an IRB-approved study, we retrospectively reviewed all high-risk lesions (HRL) identified at imaging-guided biopsy in our institution between July 1, 2014-July 1, 2017. Lesions were categorized high-risk-I (HR-I  = atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ and atypical papillary lesion) and II (HR-II = Flat epithelial atypia, radial scar, benign papilloma). Patient risk fact...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Background: Accurately measuring tumor size is challenging in invasive lobular carcinoma (ILC), which shows non-cohesive growth due to its lack of the adhesion protein E-cadherin. In the metastatic setting, ILC has a unique pattern of spread with a tendency to involve organs like the gastrointestinal tract, peritoneal lining, leptomeninges, or pleura. This results in sheet-like disease or effusions that cannot be measured on routine imaging tests, with measurable disease developing later in the disease course.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Advocacy Source Type: research
Introduction: Lobular breast cancer is less common that ductal carcinoma, and can be more difficult to diagnose by both physical examination and mammography. Previous studies have shown a general increase in lobular breast cancer rates over the 1980s-1990s, however this was during a time when the use of combined hormone replacement therapy (CHRT) – a known risk factor for breast cancer – was increased. As CHRT use has declined since the mid 2000s, this study endeavoured to evaluate current trends in the incidence of invasive lobular carcinoma (ILC) in women diagnosed with breast cancer, and to describe the 5-, ...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Local Regional Treatment – Surgery Source Type: research
(European Organisation for Research and Treatment of Cancer) New results to be presented at the 12th European Breast Cancer Conference show that a test, which looks at the activity of 70 genes in breast cancer tissue, is possible to use in the clinic to identify patients with invasive lobular carcinoma (ILC) that is at high risk of recurring and progressing.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
CONCLUSIONS: ILC metastases harbor genomic alterations that may potentially explain endocrine resistance in a large proportion of patients, and present genomic differences as compared to IDC metastases. PMID: 32943456 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
AbstractPurposeClinical trials have shown that axillary lymph node dissection (ALND) can be avoided for many breast cancer patients with limited nodal involvement. However, whether its omission is safe for those with invasive lobular carcinoma (ILC) is still questioned. We sought to evaluate the impact of ALND on recurrence-free survival (RFS) by extent of nodal disease in patients with ILC.MethodsWe performed a retrospective, cross-sectional analysis of ILC patients treated between 1990 and 2019 at our institution. Patients underwent either breast conservation surgery (BCS) or mastectomy. We used univariate and multivaria...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionUse of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Breast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous metastatic progression and that documentation of heterogeneity is important for informing future treatment strategies and prognostication. AbstractBreast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous met...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
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