Author response: Gray matter MRI differentiates neuromyelitis optica from multiple sclerosis using random forest

We thank Dr. Avasarala for the comment on our article.1 Since the majority of patients with neuromyelitis optica (NMO) were positive for anti-aquaporin-4 autoantibody, the classification results (table 2)1 are expected to remain similar after excluding seronegative patients (negative predictive value 76%). This is expected as patients with multiple sclerosis (MS) and NMO are heterogeneous in clinical and MRI assessments, and volumes in different brain regions may overlap (figure 1).1 Including other features, such as spinal cord atrophy, may increase the accuracy.2
Source: Neurology - Category: Neurology Authors: Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research