Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease

Conclusions:
The magnitude of NPS in preclinical cases, driven by sleep behavior and irritability domains, is linked to transitory metabolic dysfunctions within limbic networks vulnerable to the AD process and predicts subsequent PCC hypometabolism. These findings support an emerging conceptual framework in which NPS constitute an early clinical manifestation of AD pathophysiology.

Source: Neurology - May 8, 2017 Category: Neurology Authors: Ng, K. P., Pascoal, T. A., Mathotaarachchi, S., Chung, C.-O., Benedet, A. L., Shin, M., Kang, M. S., Li, X., Ba, M., Kandiah, N., Rosa-Neto, P., Gauthier, S., For the Alzheimer's Disease Neuroimaging Initiative Tags: PET, Alzheimer's disease, Cognitive neuropsychology in dementia ARTICLE Source Type: research