Use of RS-fMRI in Fabry disease: Do we need it?

Clinical studies have shown involvement of motor circuits independently of cerebrovascular symptoms in Fabry disease.1 In this issue of Neurology®, Cocozza et al.2 report alteration of the cortico-striatal pathway in Fabry disease and confirm the involvement of motor circuits in this pathology without cerebrovascular events. Strengths of this case-control study include the use of resting-state (RS) fMRI analysis for functional connectivity of the motor cortex in Fabry disease. They reported a deregulation of the basal ganglia and cortical and right cerebellar hemispheric motor circuits in these patients.

Source: Neurology - May 8, 2017 Category: Neurology Authors: Siniscalchi, A. Tags: EDITORIALS Source Type: research