Decreased synovial fluid ghrelin levels are linked with disease severity in primary knee osteoarthritis patients and are increased following laser therapy

Conclusions Decreased synovial fluid ghrelin levels are related to disease severity in patients with primary osteoarthritis and are increased following laser therapy. Local application of ghrelin may serve as an adjunctive therapy for knee OA.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research

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OBJECTIVES: Deteriorating functionality and loss of mobility, resulting from Parkinson's disease, may be worsened by osteoarthritis, which is the most common form of joint disease causing pain and functional impairment. We assessed the association between ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Discussion The anterior cruciate ligament (ACL) “is an intra-articular but extrasynovial collagenous structure with limited healing capacity that originates in the posteromedial aspect of the lateral femoral condyle and crosses into anteromedially to insert anterior into the intercondylar eminence of tibial articular surface.” It plays an important part as a mechanoreceptor particularly as a proprioceptor. Its main role is to prevent excessive anterior tibial translation, limits varus/valgus stress when the knee is in full extension and some rotary movements of the knee. There are ~120,000 surgeries per year m...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Stromal cell-derived factor-1a (SDF-1 α) and high mobility group box chromosomal protein 1 (HMGB1) are chemokines that can drive post-traumatic osteoarthritis (PTOA) induced by anterior cruciate ligament (ACL) injury. However, the influence of patient characteristics on expression of those chemokines remains unclear. Our aim was to det ermine the relationship between chemokine expression in synovial fluid (SF) of the ACL-deficient (ACL-D) knee and patient characteristics including time from injury, sex, and age.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
ConclusionMiR-140-5p was down-regulated while HMGB1 was upregulated in OA. MiR-140-5p could inhibit the PI3K/AKT signaling pathway and suppress the progression of OA through targeting HMGB1.
Source: Inflammation Research - Category: Research Source Type: research
Publication date: Available online 10 November 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Meijing Liu, Tyler Ward, Dan Young, Helga Matos, Yang Wei, Jo Adams, Kai YangAbstractElectrotherapy is a common therapeutic treatment used to provide pain relief. The device delivers a mild level of current via electrodes positioned on the skin to interfere with the pain signal and stimulate the release of the body’s own natural painkiller to reduce the pain. This paper presents the materials and fabrication methods used to manufacture a textile based wearable electronic textile (e-textile) with electrodes embedded ...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
In conclusion, abrogation of PI3K/AKT signaling triggered by miR‑186‑5p/CXCL13 may contribute to ON pathogenesis. These results highlight the possible clinical value of miR‑186‑5p in treatment for non‑traumatic ON. PMID: 31702033 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: Symptomatic hip and knee osteoarthritis are risk factors for falls and related fractures among the elderly population with and without Parkinson's disease. The inability to walk 500 m could be used as a simple predictive factor for the increased risk of falls among elderly populations. PMID: 31700249 [PubMed]
Source: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders - Category: Orthopaedics Tags: Clin Med Insights Arthritis Musculoskelet Disord Source Type: research
ConclusionAs a model animal, rats not only provide a convenient resource for studying human diseases but also provide the possibility for exploring the molecular mechanism of exercise intervention in diseases. This review also aims to provide exercise intervention frameworks and optimal exercise dose recommendations for further human exercise intervention research.Graphical abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Gait kinematics after total hip replacement only partly explain the differences in the joint moments in the frontal plane between hip osteoarthritis patients after hip replacement and healthy controls. The goa...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research
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