Inhibition of nitric oxide production by natural oxyprenylated coumarins and alkaloids in RAW 264.7 cells

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Salvatore Genovese, Vito Alessandro Taddeo, Serena Fiorito, Francesco Epifano, Mariangela Marrelli, Filomena Conforti A series of naturally occurring 3,3-dimethylallyloxy- and geranyloxycoumarins and alkaloids were chemically synthesized and tested as anti-inflammatory agents for their inhibitory effects on nitric oxide production in LPS-stimulated RAW 264.7 cells. Results indicated that the alkaloid of fungal origin 3-methylbut-2-enyl-4-methoxy-8-[(3-methylbut-2-enyl)oxy]quinoline-2-carboxylate, commonly known as Ppc-1, and coumarins having an unsubstituted 2-benzopyrone ring exhibited the highest activity with IC50 values from 23 to 34μM without having poor or not detectable cytotoxicity. Indomethacine and L-NAME used as reference drugs provided by far less activities. Graphical abstract

Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research