Cytotoxic sesquiterpene lactones from Artemisia anomala

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Lu Li, Hongchun Liu, Chunping Tang, Sheng Yao, Changqiang Ke, Chenghui Xu, Yang Ye Two new sesquiterpene lactones, 8α-acetoxy-1,10α-epoxy-2-oxo-guaia-3,11(13)-dien-12,6α-olide (1) and 13-acetoxy-1-oxo-4α-hydroxy-eudesman-2(11)-dien-12,6α-olide (2), along with six known analogs (3-8), were isolated from the whole plant of Artemisia anomala S. Moore. Their structures were elucidated by extensive analysis of spectroscopic data. Compounds 6 and 7 exhibited in vitro moderate cytotoxicity against A549 cells with IC50 values of 0.6 and 0.9 μM, and HepG2 cells with IC50 values of 5.4 and 3.0 μM, respectively. Graphical abstract

Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research