Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L.

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Truong Van Nguyen Thien, Vi Ha Thi Huynh, Loan Kieu Thi Vo, Nhan Trong Tran, Thuat My Luong, Tho Huu Le, Toan Phan Duc, Quang Ton That From the leaves of Bidens pilosa L., the n-hexane, chloroform, and aqueous extracts exhibited in vitro α-glucosidase inhibitory activity, with IC50 values of 235.8, 125.6, and 100.3μg/mL, respectively. Two new compounds, methyl 4-O-caffeoyl-2-C-methyl-d-erythronate (1) and 4-O-methylokanin (2), and seven known compounds were isolated from these extracts. The chemical structures of 1–9 were elucidated on the basis of NMR spectroscopic analysis. The caffeoylquinic acid derivatives were isolated from the aqueous extract, and showed significant α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 74.7μM. Graphical abstract

Source: Phytochemistry Letters - May 5, 2017 Category: Chemistry Source Type: research