PodMed – Week of May 8, 2017

This week’s topics include lowering cholesterol and outcomes, a new agent for ulcerative colitis, handgun purchases after mass shooting events, and bystander CPR and long term outcomes. Program notes: 0:31 Handgun purchases after mass shootings 1:31 Tripled over time period 2:31 Constraints on gun research 2:45 Bystander CPR and use of defibrillators 3:45 More likely […]
Source: Johns Hopkins Medicine Weekly Health News - Category: Consumer Health News Authors: Tags: Digestive Disorders Heart And Vascular PodMed Safety Source Type: podcasts

Related Links:

Abstract One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lead to chronic intestinal inflammation. Genome-wide association studies, followed by functional studies, have identified a role for numerous autophagy genes in IBD, especially in Crohn disease. Studies using in vitro and in vivo models, in addition to human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Abstract Cytochromes P450s (CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. About 80% of currently used drugs and environmental chemicals comprise exogenous substrates for CYPs. Genetic polymorphisms of CYPs may affect the enzyme functions and ...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
FINDINGSPeptides that mimic  the function of HDL cholesterol, which has been dubbed “good cholesterol,” can treat the underlying inflammation associated with inflammatory bowel disease, or IBD, according to new research in mice. The same work revealed new details on how IBD can develop and what other types of drugs may wo rk to treat the disease.BACKGROUNDThe most common types of IBD, a chronic inflammatory disease of the digestive tract, are Crohn ’s disease and ulcerative colitis. There are few effective treatments for IBD, and a majority of patients will eventually need surgery, according to previ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Millennials are often credited with driving the $4.2 trillion global wellness market, with their love of pursuits like yoga, meditation and boutique fitness. But despite their reputation for valuing health and wellness, millennials are in worse health than their elders in Generation X used to be, according to a new report from the Blue Cross Blue Shield Association. Millennials — who in 2017 were ages 21 to 36 — were overall in good health that year, according to Blue Cross’s data analysis of 55 million commercially insured millennials. But around age 27, millennials’ health began to decline —...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
Geng-Hong Xia1†, Chao You1,2†, Xu-Xuan Gao1, Xiu-Li Zeng1, Jia-Jia Zhu1, Kai-Yu Xu3, Chu-Hong Tan1, Ruo-Ting Xu1, Qi-Heng Wu1, Hong-Wei Zhou3, Yan He4*‡ and Jia Yin1*‡ 1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China 2Department of Neurology, The First People's Hospital of Zunyi, Zunyi, China 3State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China 4Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical Univ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This holiday season we are all in search of the perfect gift. What is the one thing you truly desire for yourself and your family? Don’t you think we all want it? What if you were handed a beautifully wrapped box containing a miraculous tool that caused dramatic weight loss without limiting calories or requiring exercise? What if this gift reduced appetite, shrunk belly fat, dropped your dress size into the single digits, and accomplished all of this while sparing you from a Biggest Loser sob fest? What if that same gift freed you from acid reflux, heartburn, bowel urgency, and diarrhea, but also improved mood, incre...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Dr. Davis Gliadin gluten gluten-free grain-free grains wheat belly Source Type: blogs
ConclusionsThis case highlights the occurrence of Fournier ’s gangrene as an extremely rare but life-threatening complication during neoadjuvant radiotherapy for rectal cancer which should be refreshed in the awareness of radiation oncologists and radiologists.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
CONCLUSIONIn this study we examined the association between different CIMs and a wide variety of metabolic changes. To our knowledge it is the first comprehensive epidemiological study linking the phenotypical presentation of MPNs in a general population of more than 20.000 individuals with a broad spectrum of metabolic disturbances.With chronic inflammation being proposed as a trigger and consequence of both MPNs and metabolic syndrome and considering the results in the present study it is intriguing to postulate chronic inflammation as the common denominator in both metabolic syndrome leading to MPNs and MPNs leading to ...
Source: Blood - Category: Hematology Authors: Tags: 634. Myeloproliferative Syndromes: Clinical: Poster III Source Type: research
More News: Cardiology | Cholesterol | Health | Heart | Inflammatory Bowel Disease | Ulcerative Colitis