Assessment of urinary pharmacokinetics and pharmacodynamics of orbifloxacin in healthy dogs with ex vivo modelling.

CONCLUSION: The fluctuation of UBTs closely correlated with that of urine concentration, and UBT values depended on the susceptibility of the bacterial strains to OBFX. We believe that ex vivo modelling to determine UBTs is useful to evaluate the urinary PK/PD of antimicrobials indicated for UTIs in dogs.
PMID: 28470147 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - May 4, 2017 Category: Microbiology Authors: Shimizu T, Harada K, Manabe S, Tsukamoto T, Ito N, Hikasa Y Tags: J Med Microbiol Source Type: research