European ADPKD forum launches

The European ADPKD Forum (EAF) has been created, which is a new multidisciplinary group of leading medical and patient group experts dedicated to improving the health and quality of life of people with autosomal dominant polycystic kidney disease (ADPKD).
Source: Pharmacy Europe - Category: Drugs & Pharmacology Authors: Tags: Nephrology Autosomal dominant polycystic kidney disease genetic kidney disease Latest News multidisciplinary expert group Source Type: news

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Authors: Poch E, Rodas L, Blasco M, Molina A, Quintana L Abstract Tolvaptan is an orally active antagonist of vasopressin (antidiuretic hormone [ADH]) V2 receptors. By blocking water reabsorption in kidney collecting ducts, it prompts renal free-water excretion and has been used for the treatment of hyponatremia, both euvolemic due to the syndrome of inappropriate ADH secretion, and hypervolemic due to liver cirrhosis and congestive heart failure. In the past few years, it has been shown that vasopressin and its second messenger cyclic adenosine monophosphate (cAMP) play an important role in the pathogenesis of aut...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Obstructive kidney disease is a common urologic diagnosis and includes kidney stones, polycystic kidney disease, and renal artery stenosis. Kidney stones are a common emergency department admission in the United States. Men are affected more than women. Polycystic kidney disease is a genetic renal disease that may not reveal symptoms until an individual reaches age 30 years. Renal artery stenosis contributes to decreased perfusion to the kidneys, which contributes to hypertension and end-stage renal disease.
Source: Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
ConclusionTIPS placement in pediatric patients has high technical success with excellent resolution of variceal hemorrhage and ascites. TIPS revision was required in nearly half of the cohort, with hepatic encephalopathy common after shunt placement.
Source: Pediatric Radiology - Category: Radiology Source Type: research
Publication date: 1 November 2018Source: Life Sciences, Volume 212Author(s): Ming-Yang Chang, Chun-Yih Hsieh, Chan-Yu Lin, Tai-Di Chen, Huang-Yu Yang, Kuan-Hsing Chen, Hsiang-Hao Hsu, Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Chih-Wei YangAbstractAimsCelastrol, a naturally occurring pentacyclic triterpene, has attracted considerable interest because it exhibits potent anti-inflammatory and anti-tumor properties. However, the effects of celastrol in autosomal dominant polycystic kidney disease (ADPKD) remain uninvestigated.Main methodsWe determined the effects of celastrol on ADPKD progression in a novel Pkd1-hypomo...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: Our meta-analysis found that the outcomes of given population of PKD patients on PD were at least not inferior as compared to those with other primary kidney diseases, and suggested that PKD might be not absolutely a contraindication for PD. Given the limitations of the proposed, it needs further large-scale studies to assess whether PD is a suitable RRT option for end-stage renal disease (ESRD) patients with PKD.Kidney Blood Press Res 2018;43:1539 –1553
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): M. Tecilla, M. Bielli, F.C. OriggiSummaryA 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Microscopically, renal medullary cysts and...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Steven J. Kunnen, Tareq B. Malas, Chiara Formica, Wouter N. Leonhard, Peter A.C. ’t Hoen, Dorien J.M. PetersAbstractMutations in the PKD1 or PKD2 genes are the cause of autosomal dominant polycystic kidney disease (ADPKD). The encoded proteins localize within the cell membrane and primary cilia and are proposed to be involved in mechanotransduction. Therefore, we evaluate shear stress dependent signaling in renal epithelial cells and the relevance for ADPKD. Using RNA sequencing and pathway analysis, we compared gene express...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Lilah Joiner, from Carthage, Mississippi, was born with autosomal recessive polycystic kidney disease (ARPKD).
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
Autosomal dominant PKD gets an atomic map, Published online: 02 October 2018; doi:10.1038/s41581-018-0066-7The polycystin complex structure has been solved at near-atomic resolution. Its surprising architecture provides new insights into the transient receptor potential (TRP) family of cation channels and the pathogenesis of autosomal dominant polycystic kidney disease. This discovery should have a transformative impact on the development of treatment strategies to cure the disease.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Upon completion, participant will be able to describe what patients with ADPKD are currently eating and compare their diet to recommendations.
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Sunday, October 21 Source Type: research
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