Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease.

In conclusion, in mice with streptozotocin-induced diabetes and humans with DKD, urine concentrations and enzymatic activities of several RAS components are concordantly increased, consistent with enhanced RAS activity and greater angiotensinII formation. ACEI use was associated with a specific reduction in urine ACE activity, not ACE protein concentration, suggesting it may be a marker of exposure to this therapy. PMID: 28468961 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research