TRAF3/CYLD mutations identify a distinct subset of human papillomavirus ‐associated head and neck squamous cell carcinoma

CONCLUSIONSDefects in TRAF3/CYLD were accompanied with the activation of nuclear factor κB signaling and maintenance of episomal HPV in tumors, suggesting that these mutations may support an alternative mechanism of HPV tumorigenesis in head and neck tumors. Cancer 2017;123:1778–1790. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Source: Cancer - March 13, 2017 Category: Cancer & Oncology Authors: Michael Hajek, Andrew Sewell, Susan Kaech, Barbara Burtness, Wendell G. Yarbrough, Natalia Issaeva Tags: Original Article Source Type: research