Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing.

CONCLUSIONS: ASCs and BMP-12 accelerated the progression of healing in the proliferative stage of tendon repair. The effects of ASCs and BMP-12 on tendon functional recovery should be evaluated in future studies. CLINICAL RELEVANCE: The cell sheet approach is an effective, biocompatible, and surgeon-friendly approach for cell and growth factor delivery during tendon repair. Combined application of ASCs and BMP-12 may accelerate intrasynovial tendon healing while suppressing the adverse inflammatory response. PMID: 28462460 [PubMed - as supplied by publisher]
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research

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ConclusionsIn our study cohort, early surgery for PFV achieved functional visual acuity in about one-third of patients. Limbal approach to surgery may result in better visual acuity and anatomic results.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
(CNN) — Should you eat before or after exercise in the morning? The debate has raged for years. The eat-first camp says food before exercise boosts blood sugars, giving the body fuel to increase the intensity and length of a workout. It also keeps you from being fatigued or dizzy. The eat-after camp says you burn more fat if you fast before exercise. A small UK study published Friday supports the latter point of view: In 30 obese or overweight men, those who exercised before breakfast burned twice the fat as men who ate breakfast before they worked out. That’s because exercising with no fuel forces the body to ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Exercise Source Type: news
ConclusionThe present study has demonstrated that the pure and impure distinction of orbital fractures was not clinically relevant with respect to ocular and periocular injuries. However, our findings seem to suggest that other parameters such as the direction of the impact and/or its magnitude, rather than merely the pure or impure configuration, could be involved in determining the risk of developing concomitant ocular and periocular injuries.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Amely Hartmann, Claudia Welte-Jzyk, Bilal Al-Nawas, Monika DaubländerSummaryThe aim of this study was to evaluate if patients after orofacial cleft repair experience neurophysiological changes with consecutive chronic pain states after surgery.Patients (n=48) with a repaired orofacial cleft (CLP) recruited in a support group took part in a survey including five questionnaires. They revealed pain states, described cleft situation and history, and epidemiological data. Patients’ quality of life and psycholog...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Condition:   Botulinum Toxin, Component Separation, Rives Repair, Large Hernia Intervention:   Procedure: botulinum toxin type A Sponsor:   Hospital Universitario La Fe Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Dry Eye;   Cataract Surgery;   Patient Related Outcome Measures;   Patient Satisfaction Interventions:   Drug: AEONTM Repair;   Other: Routine post-operative eye drops used. Sponsors:   Guy's and St Thomas' NHS Foundation Trust;   City, University of London;   King's College London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we synthesized a membrane-permeable peptide (Tat-CDK5-CTM) that specifically disrupts the binding of CDK5 and NR2B and then leads to the degradation of CDK5 by a lysosome-mediated pathway. We found that the administration of Tat-CDK5-CTM not only retards calcium overload and neuronal death in oxygen and glucose deprivation (OGD)-treated neurons but also reduced the infarction area and neuronal loss and improved the neurological functions in MCAO (middle cerebral artery occlusion) mice. The peptide-directed lysosomal degradation of CDK5 is a promising therapeutic intervention for stroke. Link:...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Moraveji S, Adler DG, Dargan A, Moraveji S, Pourshams I, Siddiqui A Abstract BACKGROUND: There is currently limited long-term data regarding the clinical outcomes of endoscopic stents as an alternative for emergency surgery in the treatment of acute esophageal perforation. Our aim was to compare the long-term outcomes of endoscopic stenting with those of surgery for patients with acute esophageal perforation. METHODS: We performed a retrospective study of acute esophageal perforation patients who underwent insertion of esophageal stents (N.=80) or surgery (N.=85) for treatment. The primary endpoint was...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
The objective of this study was to evaluate whether superior capsule reconstruction (SCR) for reinforcement before arthroscopic rotator cuff repair (ARCR) improves cuff integrity.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Retears are a common complication after surgical repair of large and massive rotator cuff tears. Basic fibroblast growth factor (b-FGF) and platelet rich plasma (PRP) reportedly enhance the healing of rotator cuff tears. The purpose of this study was to evaluate the efficacy of PRP and b-FGF using a gelatin hydrogel sheet (GHS), which preserves these healing factors and facilitates their sustainable release until degradation of the sheet during the early healing of rotator cuff tear using a rat model.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
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