Depressive symptoms are found to be potential adverse effects of androgen deprivation therapy in older prostate cancer patients: a 15 ‐month prospective, observational study
Abstract ObjectivesTo evaluate the association between androgen deprivation therapy (ADT) and depression and to identify the risk factors for depressive symptoms among prostate cancer patients who received ADT. MethodsWe conducted a prospective, longitudinal, controlled study and assessed three groups of older patients: the ADT group (men who were presented with maximum androgen block); the radical prostatectomy group (RP) (PCa control group: men who underwent radical prostatectomy without ADT); and the BPH group (men who had benign prostatic hyperplasia). All patients completed the demographic questionnaire at baseline and the Zung Self‐Rating Depression Scale (SDS) at pretreatment baseline, 1 month, 6 months, 9 months, 12 months and 15 months. ResultsA total of 146 patients completed the study during the 15‐month follow‐up. The SDS scores of the three groups showed significant differences at 1 month (p
CONCLUSIONS: Results suggest that the CES-D is a valid screening instrument for depressive disorders in military samples with a history of mTBI. PMID: 31017474 [PubMed - as supplied by publisher]
CONCLUSIONS: AMS predicts post-mTBI depressive symptoms both in the acute and chronic mTBI phases whereas LOC is a more sensitive predictor of post-concussive symptoms in the acute mTBI period. PMID: 31017017 [PubMed - as supplied by publisher]
This study examined how two aesthetic features of infographics affect people's evaluation of information presented in infographic: colour and visual complexity. The findings suggested colour and visual complexity were both strong predictors of information evaluation in infographic and they should be chosen carefully in the design of infographics. PMID: 31014148 [PubMed - as supplied by publisher]
In conclusion, it was identified that silencing of miR‑193a‑3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling. The function of miR‑193a‑3p in HER2 positive breast cancer implicates its potential application in therapy. PMID: 31017268 [PubMed - in process]
MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α. Int J Mol Med. 2019 Jun;43(6):2387-2397 Authors: Hu Q, Liu F, Yan T, Wu M, Ye M, Shi G, Lv S, Zhu X Abstract The most common and aggressive type of brain cancer in adults is glioblastoma multiforme (GBM), and hypoxia is a common feature of glioblastoma. As the histological features of glioma include capillary endothelial cell proliferation, they are highly prone to invading the surrounding normal brain tissue, which is often one of the reasons for the ...
Detection of N6‑methyladenosine modification residues (Review). Int J Mol Med. 2019 Jun;43(6):2267-2278 Authors: Zhu W, Wang JZ, Xu Z, Cao M, Hu Q, Pan C, Guo M, Wei JF, Yang H Abstract Among a number of mRNA modifications, N6‑methyladenosine (m6A) modification is the most common type in eukaryotes and nuclear‑replicating viruses. m6A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m6A methyltransferases are essential during RNA modifications, the biological functions of m6A and the underlying mechanisms rem...
In conclusion, IL‑18 served a dual function in colitis by regulating the function of goblet cells. The anti‑inflammatory effects of IL‑18 were observed in the early stage of colitis‑induced inflammation, while the pro‑inflammatory effects were observed in the later stages of the disease. PMID: 31017261 [PubMed - in process]
CONCLUSIONS: Results demonstrated that 1 D displayed favourable pharmacokinetic properties for further in vivo pharmacologic evaluation, which could be facilitated by the validated LC-MS/MS method. PMID: 31017510 [PubMed - in process]
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ00470J, PaperLingfeng Gao, Wenyuan Zhuge, Xue Feng, Wei Sun, Xu Sun, Gengxiu Zheng Co3O4 nanoparticles uniformly dispersed on reduced graphene oxide (Co/rGO) were synthesized by alcohol thermal method as highly efficient catalyst with initiator NHPI for the selective oxidation of ethylbenzene to acetophenone... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC01461F, CommunicationBaoji Du, Weiqi Zhang, Ching-Hsuan Tung A multifunctional photosensitive and photothermal nanomedicine, AMP-Ce6-HA, was prepared by sequencially layering hard and soft functional molecules. AMP-Ce6-HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released... The content of this RSS Feed (c) The Royal Society of Chemistry