Depressive symptoms are found to be potential adverse effects of androgen deprivation therapy in older prostate cancer patients: a 15 ‐month prospective, observational study

Abstract ObjectivesTo evaluate the association between androgen deprivation therapy (ADT) and depression and to identify the risk factors for depressive symptoms among prostate cancer patients who received ADT. MethodsWe conducted a prospective, longitudinal, controlled study and assessed three groups of older patients: the ADT group (men who were presented with maximum androgen block); the radical prostatectomy group (RP) (PCa control group: men who underwent radical prostatectomy without ADT); and the BPH group (men who had benign prostatic hyperplasia). All patients completed the demographic questionnaire at baseline and the Zung Self‐Rating Depression Scale (SDS) at pretreatment baseline, 1 month, 6 months, 9 months, 12 months and 15 months. ResultsA total of 146 patients completed the study during the 15‐month follow‐up. The SDS scores of the three groups showed significant differences at 1 month (p 
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research

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Publication date: Available online 17 November 2018Source: The Annals of Thoracic SurgeryAuthor(s): Masaya Tamura, Isao Matsumoto, Yusuke Tanaka, Daisuke Saito, Shuhei Yoshida, Seiichi Kakegawa, Tomoyasu Kumano, Yosuke Shimizu, Hiroyasu Tamamura, Tsuyoshi Takanaka, Hirofumi TakemuraAbstractBackgroundThe aim of this study was to compare outcomes of primary treatment with stereotactic body radiation therapy (SBRT) versus sublobar resection (SLR) for clinical stage I non-small cell lung cancer (NSCLC) in patients with medical comorbidities.MethodsConsecutive patients who underwent SBRT (n=106) or SLR (wedge resection: n=100 a...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Suicide rates are highest in certain occupations, according to a CDC report.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
ConclusionsWe report a case of a 67-year-old man with hypothalamic hypopituitarism secondary to a suprasellar metastasis from a primary small cell lung cancer, and we review ten cases of hypothalamic hypopituitarism due to metastases, including our patient. Recognizing hypopituitarism can be challenging, especially in the elderly, whose symptoms such as lethargy and visual decline may be mistaken for the natural aging process. In patients with established metastatic conditions, the symptoms may be wrongly attributed to malignancy or to the side effects of therapy. When a patient is suspected of having hypopituitarism, a ho...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 16 November 2018Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donatella Feretti, Roberta Pedrazzani, Elisabetta Ceretti, Mario Dal Grande, Ilaria Zerbini, Gaia Claudia Viviana Viola, Umberto Gelatti, Francesco Donato, Claudia ZaniAbstractAir pollution has well-known harmful effects on human beings, causing both acute and chronic diseases. Some data suggest that genetic damage occurring early in life may influence the risk of having cancer and other chronic diseases in adulthood. Therefore, there is a growing interest in studying the genotoxic activit...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
ConclusionRadium-223 is a valuable therapeutic alternative in the treatment of patients with mCRPC in early stages of the disease, with a good safety profile. Its benefits extend to the bone environment.ResumenContextoEliminar las metástasis óseas, restaurar/preservar la morfología ósea y prevenir/retrasar los eventos óseos constituyen un objetivo fundamental en el manejo del cáncer de próstata resistente a la castración metastásico (CPRCm). Radio-223 es la primera terapia alfa-dirigida con acción sobre el hueso que aumenta la supervivencia en estos paci...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Publication date: December 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 6Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: December 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 6Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
This study aimed to review the effect of decision aids on men's screening intention, screening utilization, and the congruence between intentions and uptake.Evidence acquisitionData sources were searched through April 6, 2018, and included MEDLINE, Scopus, CENTRAL, CT.gov, Cochrane report, PsycARTICLES, PsycINFO, and reference lists. This study included RCTs and observational studies of decision aids that measured prostate screening intention or behavior. The analysis was completed in April 2018.Evidence synthesisEighteen studies (13 RCTs, four before–after studies, and one non-RCT) reported data on screening intenti...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsAmong women Veterans Health Administration users, examination of qualitatively distinct patterns of adversity yielded more meaningful results than counting the number of adverse events. Given the high incidence of adverse experiences, Veterans Health Administration is positioned to respond with secondary prevention and a universal trauma precautions approach to all care for women Veterans.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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