Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease.

CONCLUSION: The abnormal connectivity of the somatomotor and DMN observed in HD patients may represent an early dysfunction marker, as it preceded volume loss in DMN. Pridopidine reduced connectivity of these networks in all four treated patients, suggesting that connectivity is sensitive to treatment response.
PMID: 28464463 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - May 2, 2017 Category: Neuroscience Authors: Sánchez-Castañeda C, de Pasquale F, Caravasso CF, Marano M, Maffi S, Migliore S, Sabatini U, Squitieri F Tags: CNS Neurosci Ther Source Type: research