Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects.

Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects. Hear Res. 2017 Apr 27;350:133-138 Authors: Radziwon K, Holfoth D, Lindner J, Kaier-Green Z, Bowler R, Urban M, Salvi R Abstract The use of auditory reaction time is a reliable measure of loudness perception in both animals and humans with reaction times (RT) decreasing with increasing stimulus intensity. Since abnormal loudness perception is a common feature of hyperacusis, a potentially debilitating auditory disorder in which moderate-intensity sounds are perceived as uncomfortable or painfully loud, we used RT measures to assess rats for salicylate-induced hyperacusis. A previous study using an operant conditioning RT procedure found that high-dose sodium salicylate (SS) induced hyperacusis-like behavior, i.e., faster than normal RTs to moderate and high level sounds, when rats were tested with broadband noise stimuli. However, it was not clear from that study if salicylate induces hyperacusis-like behavior in a dose- or frequency-dependent manner. Therefore, the goals of the current study were to determine how RT-intensity functions were altered by different doses of salicylate, and, using tone bursts, to determine if salicylate induces hyperacusis-like behavior across the entire frequency spectrum or only at certain frequencies. Similar to previous physiological studies, we began to see faster than normal RTs for sounds 60 dB SPL and greater with sali...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research
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