Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies.

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies. J Inorg Biochem. 2017 Apr 26;172:138-146 Authors: Paixão DA, Marzano IM, Jaimes EHL, Pivatto M, Campos DL, Pavan FR, Deflon VM, Maia PIDS, Da Costa Ferreira AM, Uehara IA, Silva MJB, Botelho FV, Pereira-Maia EC, Guilardi S, Guerra W Abstract Five new copper(II) complexes of the type [Cu(NO)(NN)(ClO4)2], in which NO=4-fluorophenoxyacetic acid hydrazide (4-FH) or 4-nitrobenzoic hydrazide (4-NH) and NN=1,10-phenanthroline (phen), 4-4'-dimethoxy-2-2'-bipyridine (dmb) or 2,2-bipyridine (bipy) were synthesized and characterized using various spectroscopic methods. The X-ray structural analysis of one representative compound indicates that the geometry around the copper ion is distorted octahedron, in which the ion is coordinated to hydrazide via the terminal nitrogen and the carbonyl oxygen, and to heterocyclic bases via their two nitrogen atoms. Two perchlorate anions occupy the apical positions, completing the coordination sphere. The cytotoxic activity of compounds was investigated in three tumor cell lines (K562, MDA-MB-231 and MCF-7). Concerning K562 cell line, the complexes with 1,10-phenanthroline exhibit high cytotoxic activity and are more active than carboplatin, free ligands and [Cu(phen)2](2+). Considering the cytotoxicity results, further investigations for the compounds [Cu(4-FH)(phen)(ClO4)2] I and [Cu(4-NH)(phen)...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research