Two cytotoxic triterpenes from cultures of a Kenyan Laetiporus sp. (Basidiomycota)

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Clara Chepkirui, Josphat Clement Matasyoh, Cony Decock, Marc Stadler HPLC profiling of the mycelial culture of a poroid basidomycete collected in Mount Elgon, Kenya, which probably represents a new species of the genus Laetiporus, led to isolation of two previously undescribed lanostane type triterpenes.We propose the trivial names laetiporins A (1) and B (2). In addition, five known ones: dehydrosulphurenic acid (3), sulphurenic acid (4), eburicoic acid (5), 15α-hydroxytrametenolic acid (6) and trametenolic acid (7) were also isolated. The laetiporins (1–2) exhibited significant cytotoxic effects against various human cancer cells. The known compounds (3–5) and (7) also showed moderate cytotoxic activity, but none of the compounds showed any significant antimicrobial activity. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research