Bioactive mexicanolide-type limonoids from the fruits of Trichilia connaroides

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): A-Hong Chen, Qing Wen, Yan-Lei Ma, Zhi-Hua Jiang, Qing-Long Liu, Jin-Ying Tang, Wei Xu, Yan-Ping Liu, Yan-Hui Fu Two new mexicanolide-type limonoids, trichiconnarones A (1) and B (2), along with six known analogues (3–8), were isolated from the fruits of Trichilia connaroides. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC50 values comparable to that of hydrocortisone. Graphical abstract

Source: Phytochemistry Letters - May 3, 2017 Category: Chemistry Source Type: research