Cutting-Edge Infertility Treatments Cutting-Edge Infertility Treatments

From'mini IVF'to uterine transplantations, take a quick look at cutting-edge advances in fertility.Medscape Ob/Gyn
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Article Source Type: news

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Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Over 10% of new cancer diagnoses occur in reproductive aged women, impacting 87 per 100,000 women each year [1]. Improvement in the management and treatment of these patients is leading to improved survival [2] and greater interest in survivorship outcomes. There is a growing movement to preserve the fullness of cancer patients ’ future. Satisfactory quality-of-life in cancer survivors may include the ability to conceive children and the infertility associated with cancer treatment can contribute to profound distress and depression in survivors [3].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Hematopoietic cell transplantation (HCT) is the only established curative therapy for sickle cell disease (SCD). Rates of disease-free survival exceed 95% with a matched-sibling donor using myeloablative conditioning.1 However, busulfan-based conditioning regimens are associated with substantial morbidity and high rates of infertility, particularly in adolescent females; recipients over 16 years of age have poorer outcomes.1,2 Graft-versus-host disease (GVHD) remains a challenge and a major reason why not all children and adolescents with a matched sibling donor are offered HCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
cute; Abstract Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0.5 g/g or 0.5 g/d threshold, which calls for a renal histological evaluation in order to determine the lupus nephritis severity and the need for specific therapy. More than half of renal biopsies lead to the diagnosis of active lupus nephritis-class III or class IV A according to the ISN/RPS classification-t...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Authors: Zaami S, Di Luca A, Marinelli E Abstract Women suffering from Uterine Factor Infertility (UFI) arising from congenital conditions (e.g., Rokitansky-Kuster-Hauser syndrome) or hysterectomy can fulfill their wish to achieve motherhood only by resorting to surrogacy, which is, however, banned in most countries. Medical research has long been looking into uterus transplant (UTx), which may constitute a valuable alternative for such patients. Following decades of animal testing and clinical trials, several successful pregnancies have been carried to term. Yet UTx is still to be considered as an experimental pro...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Survivors of hematopoietic cell transplantation (HCT) often face infertility later in life due to preparative conditioning regimens that are harmful to reproductive function. Current American Society of Clinical Oncology (ASCO) clinical guidelines on fertility preservation (FP) recommend that all patients who are at risk for infertility due to medical treatment should be referred to a fertility specialist for counseling following diagnosis and preferably prior to the start of treatment. Despite HCT physicians ’ awareness of standard-of-care services for preserving fertility and the psychosocial sequelae resulting fro...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 85 Source Type: research
Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or conditioning, prior to BMT limit the use of this curative procedure due to regimen-related mortality and morbidities, including risks of organ toxicity, infertility and secondary malignancies. To safely condition patients for BMT, we are developing antibody drug conjugates (ADCs) targeting CD45, a target expressed throughout the hematopoietic system to specifically deplete both hematopoietic stem cell (HSCs) and immune cells prior to transplant.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 40 Source Type: research
Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or conditioning, prior to BMT limit the use of this curative procedure due to regimen-related mortality and morbidities, including risks of organ toxicity, infertility and secondary malignancies. Targeted preparation using antibody drug conjugates (ADCs) to mouse CD45 has previously been shown to be sufficient to enable bone marrow transplant (BMT) in syngeneic immune competent mice (Palchaudhuri et al.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 262 Source Type: research
Publication date: Available online 30 January 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Yuan-Jie Du, Xin Xin, Na Cui, Lei Jiang, Ai-Min Yang, Gui-Min Hao, Bu-Lang GaoAbstractObjectiveTo study the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) on thyroid function in euthyroid patients of in vitro fertilization (IVF)/ intracytoplasmic sperm injection of embryo transfer (ICSI-ET) and to investigate the timing and alteration of thyroid stimulating hormone (TSH) during controlled ovarian stimulation(COS)Materials and methodsEuthyroid patients scheduled ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 23 January 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Maria Grazia Giudice, Federico Del Vento, Christine WynsAbstractThis paper aims at reviewing the fertility preservation strategies that could be considered in several conditions at risk of spermatogonial depletion such as 46,XY disorders of sexual development, Klinefelter syndrome and after gonadotoxic treatment in males highlighting current knowledge on diseases and processes involved in infertility as well as future directions along with their specific ethical issues.While sperm cryoprese...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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