Statins side effects 'have been overstated,' says study

Conclusion This is a complex study that provides a plausible explanation for the difference in reports of adverse effects of statins in RCTs and observational studies, some of which have suggested as many as 1 in 5 people get side effects from statins. However, we need to be aware of some limitations and unanswered questions: When people knew they were taking statins, they were more likely to report muscle pain than those not taking statins. But they were less likely to report muscle pain than in the first phase of the study, when they didn't know whether they were taking statins or placebo. We don't know why this is. Almost everyone in the study was white European (95%) and male (81%). We don't know if the results hold true for people in other ethnic groups or women. Because people weren't prompted to report concerns about specific adverse events or side effects, it's possible these may have been underestimated. Also, the study only looked at one statin, and at a dose lower than those often used today. The unanswered questions mean there may be other explanations for the differences in reporting of adverse effects, other than the "nocebo" effect. NHS guidelines say doctors should consider offering statins to people who have had a prior heart attack or stroke, or to people with a 10% or higher risk of having a heart attack or stroke in the next 10 years. Statins need to be used with caution in people with a history of liver disease. There's also a very ra...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

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Publication date: Available online 25 May 2019Source: Journal of Physics and Chemistry of SolidsAuthor(s): D. Alburquenque, L. Troncoso, J.C. Denardin, J.F. Marco, J.L. GautierAbstractManganese nickel oxides with a spinel-related structure, NixMn3-xO4-δ (x = 0.5 or 0.75), were synthesized by an ultrasound-assisted sol-gel method. Inductively coupled plasma atomic optical emission spectroscopy and energy-dispersive X-ray spectroscopy analysis showed good agreement with the nominal oxide compositions. The Rietveld refinement of the X-ray data indicated that both Ni0.5Mn2.5O4-δ and Ni0.75Mn2.25O4-δ cryst...
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
Authors: Vigna L, Morelli F, Agnelli GM, Napolitano F, Ratto D, Occhinegro A, Di Iorio C, Savino E, Girometta C, Brandalise F, Rossi P Abstract Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional. We assessed whether a Hericium erinaceus treatment improved depression, anxiety, sleep, and binge eating disorders after 8 weeks of supplementation in subjects affected by overweight or obesity under a low calorie diet regimen. Looking for a possible clinical biomarker, we assessed the seru...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Ko JH, Kim SN Abstract MicroRNAs (miRNAs) are the main regulators of diverse physiological processes. Recently, miRNAs have emerged as significant players related to the effect of acupuncture although the biological mechanisms connecting the function of these miRNAs with the effect of acupuncture are not well understood. In animal models of various diseases, such as neurological disease, cardiovascular disease, myopathy, and pain, a number of miRNAs were altered after administration of electroacupuncture or manual acupuncture. Nonetheless, there are a limited number of studies published so far. This paper ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
In this study, we report that the Protium javanicum methanol extract (Pj-ME) plays an important role in suppressing nitric oxide (NO) levels without cytotoxicity. The effect of Pj-ME in LPS-induced expression leads to reduced inflammatory cytokine expression, specifically inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and tumor necrosis factor (TNF-α). Pj-ME significantly inhibited LPS-induced protein expression of the nuclear factor-kappa B (NF-κB) signaling pathway in a time-dependent manner. Syk and Src were identified as putative signaling molecules of Pj-ME-mediated anti-inflammatory activ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 24 May 2019Source: Journal of Molecular StructureAuthor(s): O. Secundino-Sánchez, J. Diaz-Reyes, J. Aguila-López, J.F. Sánchez-RamírezAbstractIn this work reports the crystalline phase transformation of electrospinning TiO2 nanofibres by annealing at high temperatures. The nanofibres chemical stoichiometry was determined by Energy-dispersive X-ray spectroscopy (EDS), which allowed find that the TiO2 crystal phase transformation is caused by oxygen vacancy generating. The TiO2 nanofibres diameter varied from 137.0 to 115.3 nm in the temperature range of 100-1000...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, the morphology of an immiscible polymer blend system at various regions of interests was analyzed using different microanalytical methods with varying surface sensitivities. As a model immiscible polymer blend, a HDPE/PP (80/20 wt%) polymer film was used. The blend film was subjected to polarized light microscopy (PLM), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM) and time of flight secondary ion mass spectrometry (ToF-SIMS). The obtained results were compared regarding the sensitivities, informational values and overall applicability of the...
Source: Micron - Category: Biology Source Type: research
Publication date: Available online 24 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Shuoshuo Yang, Yong Wang, Shan Luo, Chenjie Shan, Yibo Geng, Tinghong Zhang, Sunren Sheng, Xingjie ZanAbstractBone related implants have huge potential market in global. Improving the implant outcomes and probability of implant success are highly pursued to relieve the pain of patients and burden on native healthy system. There are growing evidence to support reactive oxygen species (ROS) directly involved in bone diseases and failure of implants. Taking advantage of the antioxidant property of tannic acid (TA) and biocom...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In this study a novel biocomposite based on the enzyme monoamine oxidase-A (MAO-A) immobilized by covalent binding on multi-walled carbon nanotubes (MWCNT) has been developed for detection of serotonin. Immobilized MAO-A (MWCNT/MAO-A) retained 94.3 % of its catalytic activity, showing good thermal and pH stability at temperatures from 35 - 40 °C and pH from 7- 8.5. A decrease of the apparent Michaelis-Menten constant was observed compared to free MAO-A indicating an improvement of its affinity towards its substrate. Evaluation of MWCNT/MAO-A by scanning electrochemical microscopy (SECM) demonstrated that the imm...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
Publication date: 1 September 2019Source: Journal of Non-Crystalline Solids, Volume 519Author(s): T.S. Soliman, S.A. VshivkovAbstractPolyvinyl alcohol (PVA) nanocomposite films embedded with iron (Fe) nanoparticles were prepared via the solution cast technique. The effect of Fe nanoparticles on the structural and optical properties of PVA nanocomposite films were investigated using X-ray diffraction, a scanning electron microscope, and UV–Vis spectroscopy. The size of the Fe nanoparticles was calculated using the Debye–Scherrer equation, and it was found that there was an increase in nanoparticle size after dis...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
Publication date: 1 September 2019Source: Journal of Non-Crystalline Solids, Volume 519Author(s): Alexandre Douaud, Sandra Helena Messaddeq, Younès MessaddeqAbstractPhoto-induced phenomena are investigated in new metastable Agx(As20S80)100-x chalcogenide thin-films prepared by the co-evaporation technique. Under irradiation using an Ar laser at 488 nm, periodic ripples structures formation are observed inside of the irradiated spot. With an increasing irradiation time or power density, a characteristic evolution of ripples is observed from a random structure to a series of generally aligned peaks-and-valleys perio...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
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