Methicillin ‐resistant Staphylococcus aureus: a controversial food‐borne pathogen
Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is a major cause of severe healthcare‐associated (HA) infections. Although during the last decade the incidence of HA invasive infections has dropped, the incidence of community‐associated MRSA (CA‐MRSA) infections has risen among the general population. Moreover, CA‐MRSA, livestock‐associated MRSA (LA‐MRSA) and HA‐MRSA (HA‐MRSA) can be found in foods intended for human consumption. Several studies from different geographical areas have reported the presence of enterotoxin genes in several MRSA food isolates. Molecular typing studies have revealed genetic relatedness of these enterotoxigenic isolates with isolates incriminated in human infections. The contamination sources for foods, especially animal‐origin foods, may be livestock as well as humans involved in animal husbandry and food‐processing. Under favourable environmental conditions for growth and enterotoxin production, enterotoxigenic S. aureus isolates present in foods can cause staphylococcal food poisoning (SFP), irrespective of the contamination origin. Owing to the typically moderate clinical manifestations of SFP, the S. aureus strains responsible for SFP (cases or outbreaks) are frequently either not identified or not further characterized. Antimicrobial susceptibility testing is rarely performed, because administration of antimicrobial therapy is not required in the vast majority of cases. Staphylococcal food poisoning...
Microbial Drug Resistance, Ahead of Print.
Conclusion: Our results suggest that linezolid as an alternative to vancomycin for the treatment of PNSI caused by MRS with a high rate of efficacy. PMID: 31819809 [PubMed]
Authors: Montrucchio G, Bosso S, Scanu M, Mina A, Imeneo MR, Brazzi L PMID: 31818086 [PubMed - as supplied by publisher]
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Ana Lucia D. Moro, Maria Helena Rigatto
ConclusionsOur results indicate a polyclonal dissemination of mcr-1.1 in the environment surrounding the first MCR-producing E. coli strain reported in Ecuador. Our findings support the idea of lateral dissemination of mcr-1.1 gene between unrelated E. coli isolates
ConclusionThe online server and web-interface are aimed at facilitating the health organizations and medical councils to monitor the antibiotic prescription and their consumption in real time. This will not only augment the existing policy-making regarding drug-resistance programs but also promote the collection and downstream exploratory analysis of huge amount of data to get a deeper insight into the epidemiology of tuberculosis and related diseases.
ConclusionsThe SE damaged the cell membrane, with the cytoplasm flowing out, disturbed the synthesis of total protein and phosphorus metabolism, and ultimately killed the bacteria.Graphical abstract
Date: Friday, 12 20, 2019; Speaker: Scott Olesen, Ph.D., Scientific Director, OpenBiome; Building 33; 1N09
The World Health Organization earlier this year called antimicrobial resistance—pathogens’ ability to evade medical interventions—one of the 10 largest threats to global health. In the U.S. alone, according to a recent Centers for Disease Control and Prevention (CDC) report, 35,000 people die each year due to antibiotic-resistant infections. A new study published in the BMJ points to one major propagator of the problem: doctors are prescribing antibiotics when they shouldn’t. In fact, up to 43% of U.S. antibiotic prescriptions may be “inappropriate,” according to the research. Antibioti...
AbstractThere have historically been concerns of acute kidney injury (AKI) with the use of aminoglycosides. The present study aimed to compare the AKI incidence and mortality rate between critically ill patients treated with aminoglycoside or meropenem in the intensive care unit setting using a propensity score matching approach. This cross-sectional study was conducted at two university hospitals from January 2011 to October 2017. Clinical and laboratorial data were evaluated to exclude potential confounders and to calculate the Charlson index. AKI was classified according to the Acute Kidney Injury Network criteria. All ...