Rae1/YacP, a new endoribonuclease involved in ribosome-dependent mRNA decay in Bacillus subtilis

We present a docking model of Rae1 bound to the B. subtilis ribosomal A-site that is consistent with this hypothesis and show that Rae1 cleaves optimally immediately upstream of a lysine codon (AAA or AAG) in vivo.

Source: EMBO Journal - May 2, 2017 Category: Molecular Biology Authors: Leroy, M., Piton, J., Gilet, L., Pellegrini, O., Proux, C., Coppee, J.-Y., Figaro, S., Condon, C. Tags: Microbiology, Virology & Host Pathogen Interaction, Protein Biosynthesis & Quality Control, RNA Biology Articles Source Type: research