Abstract B39: Tumor hypoxia induces DNA repair vulnerabilities through contextual "loss-of- heterozygosity"

Conclusions: Herein we illustrate through a novel mechanism of contextual "loss-of heterozygosity", which marries the tumor microenvironment and innate genetic alterations, increased sensitivity to DDR kinase inhibitors and PARPi.Citation Format: Osman Mahamud, Melvin L.K Chua, Winnie Lo, Gaetano Zafarana, Robert G. Bristow. Tumor hypoxia induces DNA repair vulnerabilities through contextual "loss-of- heterozygosity" [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr B39.

Source: Molecular Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Mahamud, O., Chua, M. L. K., Lo, W., Zafarana, G., Bristow, R. G. Tags: Exploiting Repair Defects in the Tumor Microenvironment: Poster Presentations - Proffered Abstracts Source Type: research