Abstract A28: Mutational landscape of TP53 in localized prostate cancer

Conclusions: This is the first comprehensive interrogation of the mutational landscape of TP53 in localized prostate cancer. Our findings suggest that functional TP53 loss at both the copy number and transcription level accounts for a subset of non-indolent localized prostate cancer.Citation Format: Osman Mahamud, Melvin L.K Chua, Stephane Supiot, Emilie Lalonde, Alan Dal Pra, Alejandro Berlin, Michèle Orain, Valerie Picard, Helene Hovington, Alain Bergeron, Yves Fradet, Bernard Têtu, Gaetano Zafarana, Alice Meng, Julie Livingstone, Melania Pintilie, Michael Fraser, Theodorus van der Kwast, Paul C. Boutros, Bristow G. Robert. Mutational landscape of TP53 in localized prostate cancer [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr A28.

Source: Molecular Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Mahamud, O., Chua, M. L. K., Supiot, S., Lalonde, E., Pra, A. D., Berlin, A., Orain, M., Picard, V., Hovington, H., Bergeron, A., Fradet, Y., Tetu, B., Zafarana, G., Meng, A., Livingstone, J., Pintilie, M., Fraser, M., Kwast, T. v. d., Boutros, P. C., Rob Tags: DNA Repair Gene Mutations in Cancer Genomes: Poster Presentations - Proffered Abstracts Source Type: research