Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways

The ATM protein kinase and p53 protein are both central mediators of many aspects of DNA damage and cellular stress signaling. While there is a clear, direct relationship between ATM and p53, ATM has numerous substrates in addition to p53 and, conversely, p53 can be activated by selected stresses without ATM. We have identified novel aspects of stress response signaling independently involving either ATM or p53. Though ATM plays a central role in mediating cellular responses to DNA breakage, some of the clinical abnormalities in the cancer-prone disorder, Ataxia-telangiectasia (A-T), are difficult to attribute directly to alterations in DNA damage signaling, such as neurodegeneration (primarily cerebellar), immunodeficiency, insulin resistance, progressive lung disease, and telangiectasia development. Our recent data demonstrate that, in addition to its DNA damage signaling functions, the ATM protein kinase has critical, p53-independent, non-canonical roles in modulating mitochondrial function and affecting metabolic stress signaling. It is intriguing that one gene product seems to be at a nexus of DNA damage signaling and metabolic signaling, but perhaps it should not be surprising that these pathways would be linked and that a protein with a PI-3K domain and a protein in the mTOR kinase family would provide such a link. These insights suggest that Ataxia-telangiectasia should be considered, at least in part, as a mitochondrial dysfunction disease and provide links between c...
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: DNA Damage Signaling: Oral Presentations - Invited Abstracts Source Type: research