Abstract IA12: Poisoning cancer with oxidized nucleotides by targeting MTH1

This study exemplifies a new general therapeutic approach to convert oxidative stress to cytotoxic DNA damage and cancer cell death. Here, I will present the progression of MTH1 inhibitors from pre-clinical development into early clinical trials.References:Gad et al 2014 Nature. 508(7495):215-21.Citation Format: Thomas Helleday. Poisoning cancer with oxidized nucleotides by targeting MTH1 [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr IA12.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Replication Stress: Oral Presentations - Invited Abstracts Source Type: research