Abstract PR10: Ionizing radiation-induced tumorigenesis is associated with exome-wide mutational signatures conserved in mice and humans

Conclusions: IR-induced tumorigenesis is associated with stable trinucleotide-based mutational signatures that are conserved in human malignancies and mouse malignancies. These signatures are highly distinguishable from that associated with UV. These conserved signatures, developing in multiple irradiated tissue types, may reflect mutational processes associated with in vivo IR exposure and possibly demonstrate non-lethal but pathogenic somatic variants related to DNA repair.This abstract is also being presented as Poster B42.Citation Format: Philip Davidson, Amy Sherborne, Barry Taylor, Alice Nakamura, Jean Nakamura. Ionizing radiation-induced tumorigenesis is associated with exome-wide mutational signatures conserved in mice and humans [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr PR10.

Source: Molecular Cancer Research - April 2, 2017 Category: Cancer & Oncology Authors: Davidson, P., Sherborne, A., Taylor, B., Nakamura, A., Nakamura, J. Tags: Exploiting Repair Defects in the Tumor Microenvironment: Oral Presentations - Proffered Abstracts Source Type: research