Author response: Comorbidity between central disorders of hypersomnolence and immune-based disorders

We thank Dr. Peraita-Adrados for the comment on our article.1 Our finding that narcolepsy type 1 (NT1) was not associated with increased risk of comorbid immune disorders was previously stated,2 which gave us additional confidence in our results and can be explained by a unique NT1 pathophysiology. We agree that the background in Dr. Peraita-Adrados's research was the same3; however, the methodology was different: our cohort was much larger, with patients included prospectively; the study was multicentric; adult and children populations were analyzed separately; and results were controlled for potential confounders.1 Importantly, we classified immune-based disorders in 3 groups (autoimmune, inflammatory, and allergic diseases).4 A recent article from the same group, not published at time of our submission, retrospectively added a poorly defined control group to the already reported NT1 population.3,5 Limited evidence was found for an association between heterogeneous autoimmune diseases and NT1, including psoriasis as an autoimmune, but not inflammatory, disease. We also found higher frequency of autoimmune diseases in narcolepsy type 2 and allergies in idiopathic hypersomnia, being both central disorders of hypersomnolence with unclear pathophysiology, and hypothesized on immune dysregulation mechanisms that require further study.1
Source: Neurology - Category: Neurology Authors: Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research