Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition

ConclusionsCollectively, our data indicate thatRNF20 andPARP1 are synthetic lethal interactors, suggesting that cancers with diminished RNF20 expression and/or function may be susceptible to PARP1 inhibitors.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research