Abstract B12: The effect of physical activity and body size on mammographic density in high-risk, BRCA mutation-negative women

Conclusion: In this cohort of high-risk women, high BMI was associated with lower MD that was suggestively stronger for premenopausal women. Although preliminary, these findings suggest a possible mechanism by which a lifestyle factor may influence MD, and possibly breast cancer risk, in high-risk women. Further evaluation with a larger sample size is needed to elucidate the relationships between physical activity, as well as other modifiable factors, and MD in this cohort of women. This study adds to the growing evidence supporting the inclusion of MD into breast cancer risk prediction models, in order to improve individualized treatments and prevention strategies for women at an increased risk for disease.Citation Format: Olivia M. Moran, Dina Nikitina, Anoma Gunasekara, Martin J. Yaffe, Kelly A. Metcalfe, Steven A. Narod, Joanne Kotsopoulos. The effect of physical activity and body size on mammographic density in high-risk, BRCA mutation-negative women. [abstract]. In: Proceedings of the AACR Special Conference: Improving Cancer Risk Prediction for Prevention and Early Detection; Nov 16-19, 2016; Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(5 Suppl):Abstract nr B12.

Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Moran, O. M., Nikitina, D., Gunasekara, A., Yaffe, M. J., Metcalfe, K. A., Narod, S. A., Kotsopoulos, J. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Poster Presentations - Proffered Abstracts Source Type: research