Abstract PR05: Does a comprehensive family history of colorectal cancer improve risk prediction?

Conclusion: Our CRC prediction model that incorporates more comprehensive family history of CRC can provide improved calibration and discrimination of risks compared with the simple FH model, especially in populations with higher underlying risk. The models developed may potentially further improve screening decision making among subgroups with elevated CRC risk.References:1. Freedman AN, Slattery ML, Ballard-Barbash R, et al. Colorectal cancer risk prediction tool for white men and women without known susceptibility . J Clin Oncol 2009;27(5):686-693.2. Antoniou AC, Pharoah PDP, McMullan G, et al. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br J Cancer, 2002; 86(1), 76-83.Citation Format: Yingye Zheng, Xinwei Hua, Aung Ko Win, Mark Jenkins, Robert Macinnis, Polly Newcomb. Does a comprehensive family history of colorectal cancer improve risk prediction? [abstract]. In: Proceedings of the AACR Special Conference: Improving Cancer Risk Prediction for Prevention and Early Detection; Nov 16-19, 2016; Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(5 Suppl):Abstract nr PR05.
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research