Why is herpes simplex virus disease risk so much greater for newborns?

(Mary Ann Liebert, Inc./Genetic Engineering News) Interferon is a crucial component of the human immune system's response to infection by herpes simplex virus type 1 (HSV-1), but how important a role it plays in determining the severity of disease and explaining why newborns are so much more susceptible to HSV-1 infection than adults remains unclear.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Herpes simplex is a very common virus that affects billions of people globally. It can cause sores around the mouth or on the genitals and surrounding areas. Learn more about herpes simplex here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Ujjaldeep Jaggi, Shaohui Wang, Kati Tormanen, Harry Matundan, Alexander V. Ljubimov, Homayon Ghiasi
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractPeripheral nerve injury downregulates the expression of the μ-opioid receptor (MOR) and voltage-gated potassium channel subunit Kv1.2 by increasing their DNA methylation in the dorsal root ganglion (DRG). Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) causes DNA demethylation. Given that DRG MOR and Kv1.2 downregulation contribute to neuropath ic pain genesis, this study investigated the effect of DRG TET1 overexpression on neuropathic pain. Overexpression of TET1 in the DRG through microinjection of herpes simplex virus expressing full-length TET1 mRNA into the injured rat DRG significantly allevi...
Source: Neurotherapeutics - Category: Neurology Source Type: research
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Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
Conclusions: Cytomegalovirus was the most commonly detected herpesvirus in patients with corneal endotheliitis and high IOP. A positive PCR result was seen more frequently in male individuals and patients with fine kps or a history of uveitic glaucoma.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
In this study, we determined that activation of LXR by 25HC or synthetic ligands [T0901317 (T317) or GW3965] inhibited infection of herpes simplex virus type 1 (HSV-1) or MLV-(VSV)-GFP in HepG2 cells or RAW 264.7 macrophages. Genetic deletion of LXRα, LXRβ, or CH25H expression in HepG2 cells by CRISPR/Cas9 method increased cell susceptibility to HSV-1 infection and attenuated the inhibition of LXR on viral infection. Lack of interferon (IFN)- expression also increased cell susceptibility to viral infection. However, it attenuated, but did not block, the inhibition of LXR on HSV-1 infection. In addition, expressi...
Source: The Journal of Lipid Research - Category: Lipidology Authors: Tags: Research Articles Source Type: research
Conclusion: These works are of significance for the further study of the functions of BFLF2 during EBV infection, as well as for further insights into the design of new antiviral drug target and vaccine development against EBV.Cell Physiol Biochem 2018;51:1500 –1517
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: Available online 28 November 2018Source: Microbial PathogenesisAuthor(s): Ayesha Javed, Fahed Parvaiz, Sobia ManzoorAbstractBacterial Vaginosis (BV) is a complex polymicrobial infection of vagina that shifts the paradigms of vaginal flora from lactobacilli to opportunistic pathogens. BV is catagorized by greyish white discharge, pH greater than 4.5. It results in the preterm labor, abortion, pelvic inflammatory disorders, post cesarean infections. BV is associated with Sexually Transmitted Diseases (STDs) or immune deficiency disorders like Human Immunodeficiency Virus, Human Papilloma Virus, Herpes Simpl...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Abstract We have developed a stable Chinese Hamster Ovary (CHO) cell line for the production of a recombinant monoclonal antibody (mAb) to a short protein sequence derived from the N-terminus of human herpes simplex virus type 1 glycoprotein D (HSV-1 gD). The antibody (designated r34.1) provides a useful tool for the immunoaffinity purification of HSV-1 gD tagged proteins, and provides a generic purification system by which various proteins and peptides can be purified. Recombinant 34.1 was assembled using cDNA derived from a HSV-1 gD specific murine hybridoma engineered to encode a full-length IgG molecule. Antib...
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Tags: J Immunol Methods Source Type: research
In this study, a retrospective study was conducted in 86 cases of patients with glioblastoma after neurosurgery combined with chemoradiotherapy, and 36 cases with traumatic brain injury. Our results showed that miR‐145 was significantly lower in glioblastoma tissues th an that in normal brain tissue (P 
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
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