Why is herpes simplex virus disease risk so much greater for newborns?
(Mary Ann Liebert, Inc./Genetic Engineering News) Interferon is a crucial component of the human immune system's response to infection by herpes simplex virus type 1 (HSV-1), but how important a role it plays in determining the severity of disease and explaining why newborns are so much more susceptible to HSV-1 infection than adults remains unclear.
CONCLUSION: ANE is a distinctive type of acute encephalopathy with diverse clinical spectrum. Even though the diagnostic criteria are available, they might not be watertight. In addition, treatment options are still limited. Further studies for better outcome are needed. PMID: 31099193 [PubMed - in process]
ConclusionThis compound is readily accessible in bulk quantities, is inexpensive, and has a long history of human consumption, which endorses the idea for further assessment as an antiviral therapeutic. This work also suggests that a more exhaustive assessment of natural product libraries against EBOV and other viruses is warranted to improve our ability to identify compounds that are so distinct from FDA approved drugs.
Herein we demonstrate that ultraviolet light–inactivated Herpes Simplex Virus-1 (UV-HSV-1) stimulates peripheral blood mononuclear cells (PBMCs) to lyse both androgen-sensitive and androgen-independent prostate cancer (PrCA) cell lines, but not the benign prostatic hyperplastic epithelial cell line, BPH-1, and is 1000–10,000-fold more potent at stimulating this killing than ultraviolet light-inactivated Vesicular Stomatitis Virus, adenovirus, reovirus or cytomegalovirus. Among PBMCs, natural killer (NK) cells appear to be a major cell type involved in this killing and UV-HSV-1 appears to directly and potently s...
Several lines of evidence suggest that recombination plays a central role in replication and evolution of herpes simplex virus-1 (HSV-1). G-quadruplex (G4)-motifs have been linked to recombination events in hu...
ConclusionsWe confirmed the presence of resistance mutations within the Czech population, but for further conclusions it will be necessary to examine a higher number of isolates.
Publication date: Available online 14 May 2019Source: American Journal of OtolaryngologyAuthor(s): Neha A. Patel, Rachel Kessel, Gerald ZahtzAbstractThe management of invasive fungal sinusitis differs greatly from the management of herpes simplex virus (HSV) of the nose in immunocompromised patients. However, the diagnosis may be uncertain and a delay in treatment can lead to mortality. Here we describe the successful medical management of a series of immunocompromised pediatric patients with HSV lesions of the nose with the initial concern for invasive fungal sinusitis. The diagnosis of HSV herpes was supported by positiv...
Conclusions: In case of treatment-related side effects or failure with conventional antiviral therapies, oral valganciclovir may present an alternative for the treatment and prophylaxis of HSV keratitis.
Exposure to viruses, such as mumps, rubella, poliomyelitis, cytomegalovirus and herpes simplex viruses have been proposed as risk factors for the development of psychiatric disorders and may contribute to cognitive impairment. Reduced cognitive performance was correlated with HSV-1 seropositivity in patients with BD, while cognitive impairment has been associated with a pro-inflammatory state and inflammation as a possible factor in treatment resistance.
A 6-year-old girl had a 3-year history of systemic juvenile idiopathic arthritis that was treated with prednisone and methotrexate. She presented with painful blisters, erosions, ulcerations with surface exudation, and crusts around mouth, oral mucosa, tongue, umbilicus, and right index finger (Figure); these had been present for 40 days. Tzanck smear revealed mutinucleated giant cells. Skin biopsy taken from umbilicus revealed numerous multinucleate giant cells and ballooning degeneration of keratinocytes.
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are recombining, suggesting that live attenuated HSV-2 vaccine candidates carry a"significant risk" of recombining with circulating HSV-1 strains to form an infectious virus, researchers say.Reuters Health Information