Synthesis, structure and cytotoxicity of a series of Dioxidomolybdenum(VI) complexes featuring Salan ligands.

Synthesis, structure and cytotoxicity of a series of Dioxidomolybdenum(VI) complexes featuring Salan ligands. J Inorg Biochem. 2017 Apr 18;172:110-121 Authors: Roy S, Mohanty M, Pasayat S, Majumder S, Senthilguru K, Banerjee I, Reichelt M, Reuter H, Sinn E, Dinda R Abstract Seven hexacoordinated cis-dioxidomolybdenum(VI) complexes [MoO2L(1-7)] (1-7) derived from various tetradentate diamino bis(phenolato) "salan" ligands, N,N'-dimethyl-N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminoethane {(X=Br, Y=Me, Z=H (H2L(1)); X=Me, YCl, Z=H (H2L(2)); X=(i)Pr, Y=Cl, Z=Me (H2L(3))} and N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminopropane {(X=Y=(t)Bu, Z=H (H2L(4)); X=Y=Me, Z=H (H2L(5)); X=(i)Pr, YCl, Z=Me (H2L(6)); X=Y=Br, Z=H (H2L(7))} containing O-N donor atoms, have been isolated and structurally characterized. The formation of cis-dioxidomolybdenum(VI) complexes was confirmed by elemental analysis, IR, UV-vis and NMR spectroscopy, ESI-MS and cyclic voltammetry. X-ray crystallography showed the O2N2 donor set to define an octahedral geometry in each case. The complexes (1-7) were tested for their in vitro antiproliferative activity against HT-29 and HeLa cancer cell line. IC50 values of the complexes in HT-29 follow the order 6<7<<1<2<5<<3<4 while the order was 6<7<5<1<<3<4<2 in HeLa cells. Some of the complexes proved to be as active as the clinical referred drugs, and the greater potency...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research