In vitro activity of the novel echinocandin CD101 at pH 7 and 4 against Candida spp. isolates from patients with vulvovaginal candidiasis

Conclusions:</strong> CD101 had potent activity against all<span style="font-style:italic;">Candida</span> isolates tested, including azole-resistant strains. Although there was some reduction in activity at pH 4 versus 7, the resulting MIC values were still well below the intravaginal CD101 drug concentrations anticipated to be present following topical administration. These results support continued development of topical CD101 for the treatment of VVC/RVVC.</span>
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research