Antithymocyte globulins in renal transplantation —from lymphocyte depletion to lymphocyte activation: The doubled-edged sword

Compelling data suggest that lymphocyte depletion following T cell depleting therapy may induce prolonged CD4 T cell lymphopenia and trigger lymphocyte activation in some patients. These profound and non-reversible immune changes in T cell pool subsets are the consequence of both impaired thymic renewal and peripheral homeostatic proliferation. Chronic viral challenges by CMV play a major role in these immune alterations. Even when the consequences of CD4 T cell lymphopenia have been now well described, recent studies shed new light on the clinical consequences of immune activation.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research