Nigeria: Furore Over Efforts to Eliminate Malaria

[Guardian] As Nigeria joins the rest of the globe to celebrate the World Malaria Day (WMD), today, April 25, seven countries have been certified by the World Health Organisation (WHO) as having eliminated malaria: United Arab Emirates (2007), Morocco (2010), Turkmenistan (2010), Armenia (2011), Maldives (2015), Sri Lanka (2016) and Kyrgyzstan (2016). This certification is granted by WHO when countries achieve at least three consecutive years of zero locally-acquired cases of malaria.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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[Daily Maverick] While many politicians, world leaders and big corporations speak about the future effects of climate change, poor and impoverished nations are already struggling to battle the consequences of rising global temperatures.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Gra ça Machel Trust] The Graça Machel Trust, (GMT), the Nelson Mandela Children's Fund, (NMCF) and the Foundation for Community Development (FDC) are greatly concerned about the unfolding effects of Cyclone Idai across parts of Malawi, Mozambique and Zimbabwe. The increasing death toll and numbers of women and children uncounted for is extremely worrisome. The devastation has left communities homeless, unsafe, without food, emergency healthcare and other essential services.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Namibia Economist] The Southern African Development Community (SADC) in response to the devastation caused by the recent tropical Cyclone Idai has contributed a total of US$500,000 to assist the countries affected.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[VOA] The United Nations says the combined death toll in southern African nations affected by Cyclone Idai has exceeded 700.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
The low bioavailability of nitric oxide (NO) and its precursor, arginine, contributes to the microvascular pathophysiology of severe falciparum malaria. To better characterize the mechanisms underlying hypoargininemia in severe malaria, we measured the plasma concentrations of amino acids involved in de novo arginine synthesis in children with uncomplicated falciparum malaria (UM; n = 61), children with cerebral falciparum malaria (CM; n = 45), and healthy children (HC; n = 109). We also administered primed infusions of l-arginine uniformly labeled with 13C6 and 15N4 to 8 children with severe falciparum malaria (SM; age ra...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Fungal and Parasitic Infections Source Type: research
Plasmodium falciparum erythrocyte-binding antigen 140 (EBA-140) plays a role in tight junction formation during parasite invasion of red blood cells and is a potential vaccine candidate for malaria. Individuals in areas where malaria is endemic possess EBA-140-specific antibodies, and individuals with high antibody titers to this protein have a lower rate of reinfection by parasites. The red blood cell binding segment of EBA-140 is comprised of two Duffy-binding-like domains, called F1 and F2, that together create region II. The sialic acid-binding pocket of F1 is essential for binding, whereas the sialic acid-binding pock...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research
Publication date: Available online 22 March 2019Source: The LancetAuthor(s): Miriam K Laufer
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 22 March 2019Source: The LancetAuthor(s): Richard Kajubi, Teddy Ochieng, Abel Kakuru, Prasanna Jagannathan, Miriam Nakalembe, Theodore Ruel, Bishop Opira, Harriet Ochokoru, John Ategeka, Patience Nayebare, Tamara D Clark, Diane V Havlir, Moses R Kamya, Grant DorseySummaryBackgroundIntermittent treatment with sulfadoxine–pyrimethamine, recommended for prevention of malaria in pregnant women throughout sub-Saharan Africa, is threatened by parasite resistance. We assessed the efficacy and safety of intermittent preventive treatment with dihydroartemisinin–piperaquine as an altern...
Source: The Lancet - Category: General Medicine Source Type: research
Authors: Zeng Q, Xie L, Zhang J, Vuong C, Potter B, Aylor S, Sousa J, Black C, Li Q Abstract Particle size is an important determinant of gastrointestinal absorption of compounds administrated orally. The present study evaluates the effect of a reduction in particle size assessed by homogenization, sonication, and homogenization plus sonication on the bioavailability of imidazolidinedione (IZ), an antimalarial compound with known causal prophylactic activity and radical cure of relapsing malaria. Formulations were administrated intragastrically to mice, and blood samples were collected for LC-MS/MS analysis. The ho...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conclusion: Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans. Erythropoietin concentration is associated with malaria-related anaemia. PMID: 30894794 [PubMed - in process]
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
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