5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human ﬁbrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest.

In conclusion, our data showed that 6f, among the newly synthetic compounds, exhibited highest anti-proliferative activity by disrupting the microtubule polymerisation, causing G2/M arrest and subsequently inducing cell apoptosis in HT-1080 cells. Hence, 6f is a promising microtubule depolymerising agent for the treatment of various cancers especially human ﬁbrosarcoma. PMID: 28440465 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28440465?dopt=Abstract

Source: International Journal of Oncology - April 18, 2017 Category: Cancer & Oncology Authors: Zuo D, Pang L, Shen J, Guan Q, Bai Z, Zhang H, Li Y, Lu G, Zhang W, Wu Y Tags: Int J Oncol Source Type: research