CMR in Phenotyping the Arrhythmic Substrate

AbstractPurpose of ReviewThe purpose of this review is to explore the role of cardiac magnetic resonance imaging (CMR) in the evaluation of myocardial disorders that can present with significant cardiac arrhythmias. In addition, we explore recent developments in the field of CMR in the evaluation of such conditions, such as T1 and T2 mapping techniques. The importance of CMR as a diagnostic tool in the evaluation of such conditions lies in the fact that in routine clinical practice these conditions are encountered relatively frequently, and often important clinical decisions are made based on the findings of cardiac investigations such as CMR, e.g., decisions surrounding revascularization or implantable cardioverter defibrillator (ICD) therapy. In fact, CMR is now included in many practice guidelines (American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines et al. in J Thorac Cardiovasc Surg, 142(6):e153 –203, 2011; Authors/Task Force members et al. in Eur Heart J, 35(39):2733–79, 2014; Epstein et al. in Heart Rhythm, 5(6):934–55, 2008; Maron et al. in J Am Coll Cardiol, 42(9):1687–713, 2003) and is routinely used in the evaluation of cardiomyopathic and ischemic myocardial conditions in man y institutions.Recent FindingsAlthough late gadolinium enhancement (LGE)-CMR allows a very sensitive and reproducible qualitative assessment of myocardial replacement fibrosis, it is limited in regards to absolute quant...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

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ConclusionsEndovascular coil fiducial placement for lung SBRT is associated with high procedural success rates and lower rates of clinically relevant complications than transthoracic marker placement.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Conclusions: No safety concerns were identified from this retrospective EHR review of hospitalized adults who received a milk and molasses enema for constipation relief. The findings indicate that this treatment is safe, although further study examining its efficacy in this population is needed.
Source: AJN - Category: Nursing Tags: Feature Articles Source Type: research
CONCLUSIONS: No safety concerns were identified from this retrospective EHR review of hospitalized adults who received a milk and molasses enema for constipation relief. The findings indicate that this treatment is safe, although further study examining its efficacy in this population is needed. PMID: 31408025 [PubMed - as supplied by publisher]
Source: The American Journal of Nursing - Category: Nursing Authors: Tags: Am J Nurs Source Type: research
​BY KATIE TAUSCH, MD; ELAINA CLARK; KIMBERLY KRESS GETZINGER, MD; SHANNA C. JONES, MDA 25-year-old man with a history of depression and narcotic abuse presented to the ED seven hours after ingesting 200 loperamide 2 mg tablets. He was found unresponsive at home. He was somewhat somnolent but oriented on arrival.His blood pressure was 76/43 mm Hg, pulse rate was 62 bpm, respiratory rate was 20 bpm, temperature was 35.7°C orally, and SpO2 was 98% on room air. His physical examination was otherwise normal. He said he took the loperamide "to get high and relax." He normally took 150–200 loperami...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expression would allow pain-free stimulation. In light of these intrinsic technical advantages, optogenetic methods provide an intriguing opportunity to understand and improve current strategies to terminate cardiac arrhythmia as well as for possible pain-free arrhythmia termination in patients in the future. In th...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
A woman with epigastric pain and nausea had atrioventricular block confined to episodes of vomiting.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Abstract Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and, therefore, have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs. In this review, we discuss recent advances in understanding the structures and biological functions of VGSCs. In addition, we systematically summarize eight...
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research
Conclusion: A novel GLA mutation, c.270C>G (p.Cys90Trp), was found in a Lithuanian family with a classical form of Fabry disease in heterozygous women with predominant cardiac involvement. However, the exact manifestation of this mutation is still unclear as it is newly reported and further research must be done. PMID: 31067829 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Conclusion: Talinolol loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, increased gut permeation, reduced/no human RBC toxicity, and enhanced oral bioavailability. GRAPHICAL ABSTRACT Graphical Abstract. Self-nanoemulsifying drug delivery systems (SNEDDS) of talinolol (TAL) were developed using lipid formulation classification systems (LFCS) that improved the solubility and released the drug completely in dissolution media. In vitro toxicity studies with human red blood cells (RBC) showed that the SNEDDS formulations were n...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Athletes' performance and quality of life can be negatively affected by ADHD. Risks exist for those who take ADHD medications. More research is needed on the implications ADHD may have in specific sports, and on possible advantages of medication use. Potential deleterious effects of these medications should be addressed.
Source: Clinical Journal of Sport Medicine - Category: Sports Medicine Tags: General Review Source Type: research
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