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Prophylactic Swallow Therapy for Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Randomized Trial

AbstractEvidence supporting prophylactic swallow exercises for patients with head and neck cancer (HNC) has not been universally demonstrated. This RCT examined diet level, feeding tube use, swallow function, and quality of life (QOL) of patients undergoing chemoradiotherapy who performed prophylactic swallowing exercises. Sixty HNC patients were randomized into exercise versus control groups. Swallowing, oromotor, toxicity, and QOL data were recorded (baseline, 3, 6, 12, 24  months). Physiological swallow function was examined at baseline and 3 months. Swallow exercises were completed twice daily. Oral intake at 3 months was 10% better in the exercise group, which was not statistically significant (p = 0.49). Significant (p 
Source: Dysphagia - Category: Speech Therapy Source Type: research

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Conclusion: A clinical imaging strategy based on PET/CT demonstrated a significantly higher detection rate of distant metastasis or synchronous cancer than strategies in current clinical imaging guidelines, of which European ones primarily recommend CXR/MRI, whereas U.S. guidelines preferably point to CHCT/MRI in patients with head and neck squamous cell carcinoma.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
Authors: Arantes LMRB, de Carvalho AC, Melendez ME, Lopes Carvalho A Abstract INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates h...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
This study aimed to assess the c urrent HNC caseload in a tertiary OMFS unit.
Source: International Journal of Surgery - Category: Surgery Authors: Source Type: research
Head and neck squamous cell carcinoma (HNSCC) arises from a number of distinct locations in the upper aerodigestive tract, including the oral cavity, pharynx and larynx [1]. Whilst the treatment of local disease has improved over the last few decades, locoregionally advanced disease has remained a challenge, requiring a multimodal approach of surgery and chemo/radiation therapy [2,3]. Despite intensive efforts, the global 5-year survival of HNSCC remains poor (40 –50%), although in Australia this is now in excess of 60% [4,5].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research
The objective of this programme was to indoctrinate the most vulnerable and the least tended upon; the basics of head and neck cancers via the medium of their own kins. Voluntary village health workers were educated and trained to pick up the early signs of head and neck cancers. Oral self examination was taught to them and they went to peripheral villages to screen the population. They would refer suspicious cases to tertiary healthcare centre. The population was enlightened upon the basics of preventable measures, treatment options and rehabilitation facilities for head and neck cancer patients. Knowledge, attitude and p...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
There were an estimated 61,760 incident cases of head and neck cancer (oral cavity, pharynx, oral cavity, and larynx) in the United States in 2016, accounting for about 3.7% of all new cancer cases [1]. Among oral cavity and pharynx cancer, oral cavity cancer rates are decreasing mostly due to decreases in smoking and alcohol use [2,3]. However, cancers of the base of tongue, tonsil, and oropharynx (oropharyngeal cancer) are increasing because of increases in human papillomavirus (HPV) infection.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Squamous cell carcinoma of the head and neck (SCCHN), affecting the lips, oral cavity, pharynx, and larynx, accounts for over 650,000 new cases and 350,000 cancer deaths worldwide each year. While early stage disease is usually amenable to either surgery or radiotherapy, both with curative intents, the majority of patients still present with advanced stages. In the latter category, prognosis remains dismal because recurrences and distant metastases occur frequently, and novel treatment options are urgently needed [1,2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Abstract BACKGROUND: Tube feeding dependence is a commonly observed debilitating side-effect of curative (chemo-) radiation in head and neck cancer patients that severely affects quality of life. Prevention of this side-effect can be obtained using advanced radiation techniques, such as IMRT. For radiotherapy treatment plan optimization, it has become increasingly important to develop prediction models that enable clinicians to predict the risk of tube feeding dependence for individual patients. To develop such a tool, information regarding the most relevant prognostic factors for tube feeding dependence is necess...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Head and neck squamous cell carcinoma (HNSCC) includes epithelial cancers of the oral and nasal cavity, larynx, and pharynx and accounts for ∼350,000 deaths per year worldwide. Smoking-related HNSCC is associated with few targetable mutations but is defined by frequent copy-number alteration, the most common of which is gain at 3q. Critical 3q target genes have not been conclusively determined for HNSCC. Here, we present data indicating that MAP3K13 (encoding LZK) is an amplified driver gene in HNSCC. Copy-number gain at 3q resulted in increased MAP3K13 mRNA in HNSCC tumor samples and cell lines. Silencing LZK reduced ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Tumor and Stem Cell Biology Source Type: research
Conclusions: Our results indicate that flavonoid intake is associated with lower head and neck cancer risk. These associations suggest a protective effect of dietary flavonoids on head and neck cancer risk, and thus potential as a risk reduction strategy.
Source: Journal of Nutrition - Category: Nutrition Authors: Tags: Nutritional Epidemiology Research Articles, Research Need: Role of Nutrition in Health Maintenance Source Type: research
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