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Prophylactic Swallow Therapy for Patients with Head and Neck Cancer Undergoing Chemoradiotherapy: A Randomized Trial

AbstractEvidence supporting prophylactic swallow exercises for patients with head and neck cancer (HNC) has not been universally demonstrated. This RCT examined diet level, feeding tube use, swallow function, and quality of life (QOL) of patients undergoing chemoradiotherapy who performed prophylactic swallowing exercises. Sixty HNC patients were randomized into exercise versus control groups. Swallowing, oromotor, toxicity, and QOL data were recorded (baseline, 3, 6, 12, 24  months). Physiological swallow function was examined at baseline and 3 months. Swallow exercises were completed twice daily. Oral intake at 3 months was 10% better in the exercise group, which was not statistically significant (p = 0.49). Significant (p 
Source: Dysphagia - Category: Speech Therapy Source Type: research

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AbstractHead and neck cancer (HNC) includes a diverse range of malignancies arising commonly from mucosal epithelia of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC), the most common form of HNC, develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite global advances in cancer care, HNSCC often presents with advanced disease and is associated with poor 5-year survival of ~50%. Genotyping tumor tissue to guide clinical decision-making is becoming commonplace in modern oncology, but in the management o...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
The Mediterranean diet (MD) is a known protective factor for head and neck cancer (HNC); however, there is still a lack of studies investigating this association by HNC subsite. The aim of the present study was therefore to evaluate the association between adherence to MD and HNC overall and by cancer subsite, as well as the effect of the individual food components on HNC risk. A case–control study was carried out at the Gemelli Hospital of Rome (Italy). A total of 500 HNC cases and 433 controls were interviewed. Dietary intake was assessed through a validated food frequency questionnaire that collected information o...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Head and Neck Cancer Source Type: research
Abstract The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual‐level pooled data from 10 case‐control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non‐alcohol energy‐adjusted fiber intake and adjusted for tobacco and alc...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Head and neck squamous cell carcinoma (HNSCC), which comprises cancer of the oral cavity, pharynx and larynx, is the 6th leading malignancy worldwide. With a reported annual burden of 633,000 incident cases, 355,000 deaths, and a 5year overall survival rate ∼60%, patient prognosis remains poor as diagnosis often occurs late into disease progression when advanced stage cancer is unresponsive to therapy [1–3]. Established risk factors for HNSCC include tobacco use and alcohol consumption [4]. Human Papilloma Virus (HPV) status has also been identifie d as a risk factor for HNSCC [5,6].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Hypopharyngeal cancer has the worst prognosis of all head-and-neck cancers. Despite the introduction of various new treatment modalities, the survival rate has not changed significantly over the past several decades [1 –3]. Moreover, radical surgery, such as laryngopharyngectomy with reconstruction of the pharynx, can reduce a patient’s quality of life after surgery, because it inevitably causes loss of normal speech and swallowing function [1,4–6]. Meanwhile, concurrent chemoradiotherapy (CCRTx), which is u sed as an organ preservation strategy, could preserve organ function with comparable oncologic res...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Authors: Adelstein D, Gillison ML, Pfister DG, Spencer S, Adkins D, Brizel DM, Burtness B, Busse PM, Caudell JJ, Cmelak AJ, Colevas AD, Eisele DW, Fenton M, Foote RL, Gilbert J, Haddad RI, Hicks WL, Hitchcock YJ, Jimeno A, Leizman D, Lydiatt WM, Maghami E, Mell LK, Mittal BB, Pinto HA, Ridge JA, Rocco J, Rodriguez CP, Shah JP, Weber RS, Witek M, Worden F, Yom SS, Zhen W, Burns JL, Darlow SD Abstract The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and sa...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Head and neck cancer, considering the oral cavity and pharynx regions (oropharynx, nasopharynx and hypopharynx), has high incidence and mortality compared to other cancer types, with 529,451 cases and 292,289 deaths estimated in the world in 2012 [1]. Nonetheless, the 5-year global survival of patients with oral cavity and pharyngeal cancer improved in the last 40years, from 55% in 1975 to 1977 to 66% in 2004 to 2010 [2]. The identification of oropharynx cancer associated with HPV in 1996 [3], with a better prognosis [4], has contributed to this improvement.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Head and neck cancer encompasses a variety of malignancies of the oral cavity, larynx and pharynx. In 2015, these tumors accounted for 59,340 new cancer diagnoses in the United States and resulted in 12, 290 deaths [1]. In addition to their considerable incidence, head and neck cancers remain an epidemiological challenge because they occupy critical locations in the aero-digestive tract and portend significant disease- and treatment-related morbidity [2,3].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Authors: Giannitto C, Preda L, Zurlo V, Funicelli L, Ansarin M, Di Pietro S, Bellomi M Abstract Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. Malignant tumors of the oral cavity, oropharynx, and larynx can be treated by surgical resection or radiotheraphy with or without chemotheraphy and have a profound impact on quality of life functions, including swallowing. When surgery is the chosen treatment modality, the patient may experience swallowing impairment in the oral and pharyngeal phases of deglutition. A videofluoroscop...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Abstract BackgroundThe purpose of this study was to assess whether different tongue positions change the radiation doses to swallowing organs at risks: the pharyngeal constrictor, oral cavity, and larynx during intensity‐modulated radiotherapy (IMRT) for base of tongue (BOT) cancer. MethodsIMRT plans with Tongue‐out (IMRT‐TO) and tongue‐in position (IMRT‐TI) was compared in 3 cases. ResultsDistance from BOT to pharyngeal constrictor was increased to 1.8 ± 0.8 cm with IMRT‐TO from 0.9 ± 0.6 cm with IMRT‐TI (P
Source: Head and Neck - Category: ENT & OMF Authors: Tags: CASE REPORT Source Type: research
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