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Biodegradable Stents for Caustic Esophageal Strictures: Do They Work?

AbstractBiodegradable (BD) stents have been used for the management of various esophageal strictures (ES) but the experience of its use in caustic strictures is limited. The present study, aimed at evaluating efficacy of BD stents for the treatment of refractory caustic-induced ES, was a retrospective multi-center study conducted at three tertiary care centers in India wherein adult patients with refractory caustic induced strictures underwent placement of a BD stent. Patients were followed up for immediate complications and long term outcome. All 13 patients (39.3  ± 15.1 years) underwent successful BD stent placement. Retrosternal chest pain occurred in 2 patients and stent migration in 1 (7.6%) patient. At 3 months, restenosis with recurrence of dysphagia was seen in nine (69.2%) patients, at 6 months, 10 (77%) patients had dysphagia of whom three und erwent surgery and the remaining seven patients required dilatations. At 1 year, one patient remained asymptomatic while nine had dysphagia. The requirement for dilatation was once in 3 months in seven patients&once in a month in two patients. At 2  years, the requirement of dilatations was further reduced to once in 4–6 months in all patients. Over a 3 year follow up three (23%) patients had undergone surgery, one was free of symptoms while nine patients continued to be on periodic dilatation although the requirement had reduced to once in 4–6 mont...
Source: Dysphagia - Category: Speech Therapy Source Type: research

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This article, based on a systematic literature review, describes the pharmacological options, and indicates the future perspectives for treating trigeminal neuralgia. The article therefore provides current, evidence-based knowledge about the pharmacological treatment of trigeminal neuralgia, and suggests a practical approach to the various drugs, including starting dose, titration and side effects. Expert Commentary: Carbamazepine and oxcarbazepine are the reference standard drugs for treating patients with trigeminal neuralgia. They are effective in most patients. The undesired effects however cause withdrawal from treatm...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Abstract Pain is a common problem among elite athletes and is frequently associated with sport injury. Both injury and pain interfere with peak performance. Pain management should be based on the physiological, anatomical and psychosocial influences on the individual's pain and is not equivalent to injury management, which focuses on musculoskeletal recovery and return-to-play. This narrative review provides a foundation for understanding the differing causes and types of pain in elite athletes, thereby serving as a springboard for comprehensive pain management. PMID: 28827315 [PubMed - in process]
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Br J Sports Med Source Type: research
ebretsen L Abstract Pain is a common problem among elite athletes and is frequently associated with sport injury. Both pain and injury interfere with the performance of elite athletes. There are currently no evidence-based or consensus-based guidelines for the management of pain in elite athletes. Typically, pain management consists of the provision of analgesics, rest and physical therapy. More appropriately, a treatment strategy should address all contributors to pain including underlying pathophysiology, biomechanical abnormalities and psychosocial issues, and should employ therapies providing optimal benefit a...
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Br J Sports Med Source Type: research
Privately-held biotech Bonti said today that it launched the Lantern clinical program, evaluating its intramuscular neurotoxin injection as a non-opioid pain reliever. The first clinical trial, Lantern-1, is a Phase II study designed to assess the safety and efficacy of EB-001 in patients undergoing elective breast augmentation. Get the full story at our sister site, Drug Delivery Business News. The post Bonti kicks off Ph2 trial for neurotoxin pain-reliever appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Biotech Clinical Trials Drug-Device Combinations Pain Management Pharmaceuticals bonti Source Type: news
ConclusionsAPC can be used to treat anal HSILs in HIV‐seropositive MSM, and requires repeated treatment because of a high recurrence rate. As successful treatment of human papillomavirus (HPV) infection or eradication of the anal transitional zone remains impossible, HSIL treatment is challenging and requires long‐term follow‐up.
Source: HIV Medicine - Category: Infectious Diseases Authors: Tags: Original Research Source Type: research
Conclusion this rare presentation of acute intestinal intussusception in a patient with Blue Rubber Bleb Nevus Syndrome was further complicated with postoperative coagulation disorder. Prompt surgical evaluation is essential especially when complications are suspected. Operative treatment might be necessary in the emergent setting. Close monitoring of infectious and coagulation parameters is essential in the postoperative period, and aggressive treatment should be timely initiated when disseminated intravascular coagulation is suspected.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Better understanding task distribution related to chronic pain assessment and management can help improve team-based pain care.
Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research
I am an interventional pain physician. I spend most of my days doing spine injections with a fair amount of kyphoplasties and spinal cord stimulators thrown in as well. It seems to me that these are minor procedures that shouldn’t evoke anxiety in patients, but they do. Patients get nervous. They get anxious. I am also a singer. I had the privilege of being classically trained through my college years. Like so many other passions, singing was put on the back burner in my pursuit of medicine. Music is a blessing that I hold dear to my heart, and it has pained me to not have an outlet for this gift. When I got out of f...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Pain Management Practice Management Primary Care Source Type: blogs
It has been over 100 years since the Scottish surgeon Sir T. Kennedy Dalziel described several cases of “chronic interstitial enteritis” resulting in diarrhea, abdominal pain, and intestinal obstruction, and 75 years since Drs Burrill B. Crohn, Leon Ginzburg, and Gordon Oppenheimer from Mount Sinai Hospital in New York published their case series of “terminal ileitis” in the Journal of the Ame rican Medical Association. What we now call “Crohn's disease” has evolved from a rare medical curiosity to an all-too-common diagnosis in not only North America and Europe but also the rest of the world.
Source: Gastroenterology Clinics of North America - Category: Gastroenterology Authors: Tags: Preface Source Type: research
Conclusion and InferencesWe anticipate the findings to be a starting point for validating these autonomic metrics of pain suffering and pain coping mechanisms in other chronic pain syndromes to suggest them as biomarkers of its severity and duration for profiling and correct management of chronic pain patients. Spontaneous cardiac baroreflex responses were obtained by continuous recordings of systolic blood pressure and electrocardiogram in groups of control subjects and patients with irritable bowel syndrome (IBS) during resting baseline recording. Severity of abdominal pain in patients with IBS determines an asymmetrica...
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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