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4 Ways Researchers Are Pushing The Boundaries Of Making Babies

Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different than any of us could have ever imagined,” said Dr. Eli Adashi, a Brown University professor of reproductive medical science who specializes in ovarian biology. Researchers have fine-tuned the best ways to stimulate a woman’s ovaries, grow embryos in the lab and pick the best ones to transfer to her uterus. Improved success rates have made IVF ― once considered an experimental procedure ― the gold standard of fertility treatment. Here are some of the most inspiring breakthroughs that promise to rock fertility treatment further over the next decade: 1. Babies Made From Three People For the estimated 12,000 women in the U.S. who risk passing down devastating mitochondrial diseases, including neurological disorders, and heart and kidney problems, a new procedure can be the difference in deciding to have children or not.  Scientists h...
Source: Science - The Huffington Post - Category: Science Source Type: news

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We would like to thank Dr. Yang and his or her colleagues for their excellent and deep review of our article. In their letter to the editor,1 they made several recommendations for our article.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the recent study by Zhu et  al1 entitled “Rupture Risk of Cerebral Arteriovenous Malformations During Pregnancy and Puerperium: A Single-Center Experience and Pooled Data Analysis.” The authors performed a retrospective study to compare risk of rupture in pregnant and nonpregnant female patients with arteriovenous malfor mation (AVM) and assess current evidence regarding rupture risk of AVM during pregnancy and puerperium by pooled data analysis. They concluded that an increase in annual rate of cerebral AVM hemorrhage during pregnancy and puerperium was found.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Letter to the Editor Source Type: research
CONCLUSIONS We found for the first time that PMEF has a role in stimulating cell proliferation of hASCs at an early period, subsequently promoting bone-related gene expression and inducing the expression of related proteins to stimulate osteogenic differentiation. PMID: 29775452 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS: This study shows that direct contact with 1 week post-set MTA significantly decreases the viability of SHEDs and induced cell apoptosis. The results suggest that there is a possible cytotoxic effect of pulp tissue when there is direct contact with MTA. Different responses would be expected due to the strong alkaline characteristics of fresh mixed MTA. PMID: 29764492 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
In this study, the RNAs in the gonads of 1.5-year-old Japanese flounders were sequenced using Illumina. The miRNA expression profiles in the mature gonads of males and females were characterized. A total of 277 mature miRNAs were screened in both gonads. Among them, 25 miRNAs were expressed differently in the ovary and testis. Afterward, miR-1388 was selected for its high expression level in the ovary. Gene ontology analysis revealed that the target genes of miR-1388 were highly involved in cell-cell adhesion. Nectin2l, the target of miR-1388, is a Ca-independent cell adhesion molecule that was demonstrated to be testis-bi...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Category: Genetics & Stem Cells Source Type: research
In conclusion, these data suggest that increased prenatal Ang2 has a predominant impact on the properties of renal Na,K-ATPase in both sexes. Moreover, the enzyme is resistant to higher salt intake in offspring prenatally exposed to Ang2. PMID: 29769424 [PubMed - in process]
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Iciek R, Brazert M, Wender-Ozegowska E, Pietryga M, Brazert J Abstract Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Placental visfatin expression was by analysed by RT-PCR. We demonstrated the lowest expression of placental visfatin in women who delivered ne...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Brozek R, Kurpisz M, Koczorowski R Abstract Stem cells constitute a non-specialised cell pool able for proliferation, self-renewal and differentiation into progeny constantly replacing used up tissue and/or organ fragments. They have been observed to be present in many tissue reservoirs, including stomatognathic system. Oral cavity seems to be a particularly attractive stem cells' source as these cells are richly present and easily accessible in dental and periodontal tissues and they can be used for therapeutic purposes. Their application is also morally and ethically non-controversial. Bone tissue struct...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Authors: Kubiak GM, Tomasik AR, Bartus K, Olszanecki R, Ceranowicz P Abstract Adenosine triphosphate (ATP) is an essential substrate metabolite in human beings. Mitochondrial oxidative phosphorylation provides> 95% of ATP with the remainder derived from glycolysis or tricarboxylic acid cycle (TCA). In normal hearts, acetyl-CoA is synthesized from the β-oxidation of free fatty acids (FFA) and the oxidation of pyruvate. Pyruvate is synthesized from glycolysis and can be submitted either for decarboxylation to acetyl-CoA or for dehydrogenation to lactate. Moreover, pyruvate, as well as lactate, plays a key rol...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
In this study, we performed a mutational screening in an Apulian cohort of LHON patients and we found that 41 out of 54 subjects harbored the m.11778G>A mutation, and 13 harbored the m.3460G>A mutation. Whole mtDNA sequencing was performed in three affected subjects belonging to three unrelated m.11778G>A pedigrees to evaluate the putative synergistic role of additional mtDNA mutations in determining the phenotype. Our study suggests to include haplogroup T as a possible genetic background influencing LHON penetrance and to consider the increase of mtDNA copy number as a protective factor from vision loss regardle...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
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