4 Ways Researchers Are Pushing The Boundaries Of Making Babies

Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different than any of us could have ever imagined,” said Dr. Eli Adashi, a Brown University professor of reproductive medical science who specializes in ovarian biology. Researchers have fine-tuned the best ways to stimulate a woman’s ovaries, grow embryos in the lab and pick the best ones to transfer to her uterus. Improved success rates have made IVF ― once considered an experimental procedure ― the gold standard of fertility treatment. Here are some of the most inspiring breakthroughs that promise to rock fertility treatment further over the next decade: 1. Babies Made From Three People For the estimated 12,000 women in the U.S. who risk passing down devastating mitochondrial diseases, including neurological disorders, and heart and kidney problems, a new procedure can be the difference in deciding to have children or not.  Scientists h...
Source: Science - The Huffington Post - Category: Science Source Type: news

Related Links:

Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: Available online 22 March 2019Source: MethodsXAuthor(s): M. Mudri, S.A. Smith, C. Vander Tuin, J. Davidson, T.R.H. Regnault, A. BütterAbstractThe surgical model of congenital diaphragmatic hernia (CDH) has been utilized in exploring treatments and innovative therapies, such as tracheal occlusion (TO). The rabbit is an excellent surgical model compared to others due to lower cost, ease of care, short gestational period, and large litter size. This model is also ideal in studying lung hypoplasia of CDH because rabbit lung development is most similar to humans as alveolarization begins prior to birth an...
Source: MethodsX - Category: Science Source Type: research
Publication date: Available online 21 March 2019Source: Reproductive ToxicologyAuthor(s): Qing Chen, Jin-Yan Zhao, Xiang Xue, Gai-Xia ZhuAbstractSperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive outcomes. A total of 10 articles retrieved from the databases of PUBMED, MEDLINE, EMBASE and WANFANG were included in the meta-analysis. The results indicated that high sperm DNA fragmentation was significantly associated with lowe...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Authors: Mostafavian Z, Vakilian F, Torkmanzade L, Moghiman T Abstract Introduction: Heart failure with reduced ejection fraction (HFrEF) is a debilitating disease in which Left Ventricular Ejection Fraction (LVEF) is ≤ 40%, and it involves various organs. Regarding the novelty of stem cell therapy in HF, we aimed at studying the effect of stem cell therapy on the QoL of patients with HFrEF. Materials and Methods: In a prospective study, 30 patients diagnosed with HFrEF who had undergone stem cell injection (study group) and 30 patients with HFrEF receiving guideline-directed medical therapy (control group) were...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
We present a family in which the first child was diagnosed with dopa-responsive dystonia based on biochemical findings only. Dopa-responsive dystonia is a severe heterogeneous genetic disease. The possibly involved genes are GCH1 and TH. In their second pregnancy, the parents came for genetic counseling and prenatal diagnosis late, at 12 weeks of gestation. Genetic testing in the affected child was performed, but the results were difficult to interpret. The identified mutations were classified as VOUS - variants of unknown clinical significance. Although possibly causative, a homozygous variant in the TH gene was not repor...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
This study was conducted on 120 women (60 with postpartum depression and 60 without) in Izeh, Iran. A socio-demographic questionnaire and Beck Depression Scale were used for data collection. The ELISA method was used for measuring 25-OH vitamin D (ng). The participants were classified according to their vitamin D level as follows: 25-OH-D 30ng/ml as normal. Data were analyzed using the independent t-test or Mann-Whitney test, chi-square and logistic regression test. The mean level of vitamin D of women with postpartum depression was lower than that in normal women (16.89±7.05 vs. 21.28±7.13, p=0.001). More th...
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
Publication date: Available online 22 March 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Shi-Fen Lu, Qing-Fang Lin, Ying Li, Xiao-Juan JiangAbstractThe purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a p...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): Holly J. Kramer, Raymond R. Townsend, Karen Griffin, Joseph T. Flynn, Daniel E. Weiner, Michael V. Rocco, Michael J. Choi, Matthew R. Weir, Tara I. Chang, Rajiv Agarwal, Srinivasan BeddhuHypertension is a modifiable risk factor for cardiovascular morbidity and mortality and reduction of elevated blood pressure (BP) remains an important intervention for slowing kidney disease progression. Over the past decade, the most appropriate BP target for initiation and titration of BP-lowering medications has been an area of intense ...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
CONCLUSION: Additional genetic disorders are more frequent in those with omphalocele cases, and they are more frequently terminated during gestation that the gastroschisis fetuses. PMID: 30892123 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
More News: Babies | Babies Heart Conditions | Biology | Biomedical Science | Cardiology | Centers for Disease Control and Prevention (CDC) | Children | Cystic Fibrosis | Food and Drug Administration (FDA) | Genetics | Harvard | Heart | Heart Transplant | Infertility | Insurance | Kidney Transplant | Men | Menopause | Mitochondria | Mitochondrial Disease | Neurology | Neuroscience | Ovaries | Pregnancy | Rehabilitation | Reproduction Medicine | Science | Skin | Stem Cell Therapy | Stem Cells | Study | Urology & Nephrology | Websites | Women